Nature Communications (Jun 2017)
Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro
Abstract
Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage the actin tracks.