Nature Communications (Jun 2017)

Myosin Va molecular motors manoeuvre liposome cargo through suspended actin filament intersections in vitro

  • Andrew T. Lombardo,
  • Shane R. Nelson,
  • M. Yusuf Ali,
  • Guy G. Kennedy,
  • Kathleen M. Trybus,
  • Sam Walcott,
  • David M. Warshaw

DOI
https://doi.org/10.1038/ncomms15692
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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Cellular cargo transported along actin filaments is faced with a directional choice at an intersection. Here the authors show that myosin Va-bound cargo prefers to go straight through the intersection, and propose a model to explain this by a tug-of-war between motors on the lipid cargo that engage the actin tracks.