Molecules (Jan 2017)

Synthesis and Biological Evaluation of Novel Benzimidazole Derivatives and Analogs Targeting the NLRP3 Inflammasome

  • Liangkun Pan,
  • Nan Hang,
  • Chao Zhang,
  • Yu Chen,
  • Shuchun Li,
  • Yang Sun,
  • Zhongjun Li,
  • Xiangbao Meng

DOI
https://doi.org/10.3390/molecules22020213
Journal volume & issue
Vol. 22, no. 2
p. 213

Abstract

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A series of benzo[d]imidazole analogues of thiabenzole were synthesized and their antiinflammatory activities toward NLRP3 (nucleotide‐binding domain leucine‐rich repeat containing protein family,pyrin domain‐containing 3,also known as cryopyrin or NALP3) inflammasome were evaluated in vitro. Two lead compounds, TBZ‐09 and TBZ‐21, were identified by antiproduction of IL‐1β. In the second round of biological evaluation, based on the lead, 34 more compounds were synthesized and their in vitro anti‐inflammatory activities were investigated. Several compounds were identified as anti‐inflammatory agents that can reduce IL‐1β expression in a dosedependent manner. A preliminary structure–activity relationship is also summarized here.

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