International Journal of General Medicine (Jan 2022)

Gender-Disparities in the in-Hospital Clinical Outcome Among Patients with Chronic Kidney Disease Undergoing Percutaneous Coronary Intervention

  • Wang L,
  • Li S,
  • Mo Y,
  • Hu M,
  • Zhang J,
  • Zeng M,
  • Li H,
  • Zhao H

Journal volume & issue
Vol. Volume 15
pp. 593 – 602

Abstract

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Li Wang,1 Sha Li,1 Yihao Mo,1 Mingliang Hu,1 Junwei Zhang,1 Min Zeng,1 Huafeng Li,1 Honglei Zhao2 1Department of Nephrology, People’s Hospital of Longhua District, Shenzhen, Guangdong, People’s Republic of China; 2Department of Cardiology, Fuwai Hospital Chinese Academy of Medical Science, Shenzhen, Guangdong, People’s Republic of ChinaCorrespondence: Honglei Zhao, Tel + 86-755-23650123, Email [email protected]: The current study was to evaluate the gender-disparities in the in-hospital thrombotic and bleeding events among patients with chronic kidney disease (CKD) undergoing percutaneous coronary intervention (PCI).Patients and Methods: Patients with CKD undergoing PCI were retrospectively enrolled. Baseline characteristics, and thrombotic and bleeding events occurred during hospitalization were collected and compared by gender.Results: Compared to males (n = 558), females (n = 402) were older and more likely to have diabetes mellitus (37.1% vs 29.7%). Females had a lower estimated glomerular filtration rate (eGFR; 51.2 ± 7.9 vs 54.6 ± 5.1 mL/min/1.73m2) and were more likely to undergo urgent PCI (66.7% vs 60.2%) and use glycoprotein IIb/IIIa inhibitor (15.4% vs 7.5%) at peri-PCI period. Compared to males, females had a higher rate of in-hospital mortality which was due to thrombotic events (9.0% vs 3.4%). Females also had a higher rate of moderate-to-severe hemorrhage (8.0% vs 3.2%). After multivariable adjustment, diabetes mellitus (odds ratio [OR] 1.15 and 95% confidence interval [CI] 1.07– 1.29) and acute coronary syndrome (ACS) presentation (OR 1.53 and 95% CI 1.34– 1.93) were associated with gender-disparities in composite thrombotic events. Ageing (OR 1.10 and 95% CI 1.02– 1.33), diabetes mellitus (OR 1.21 and 95% CI 1.07– 1.40) and glycoprotein IIb/IIIa inhibitor use (OR 1.13 and 95% CI 1.02– 1.28) were associated with composite bleeding events.Conclusion: Females with CKD undergoing PCI had a higher risk of experiencing in-hospital thrombotic and bleeding events than males.Keywords: coronary heart disease, chronic kidney disease, prognosis, gender

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