Arquivos de Neuro-Psiquiatria (Sep 2024)

Intracranial compliance in patients with COVID-19: a multicenter observational study

  • Ana Flávia Silveira,
  • Marcella Barreto Santos,
  • Nelci Zanon Collange,
  • Cintya Yukie Hayashi,
  • Gustavo Henrique Frigieri Vilela,
  • Samantha Longhi Simões de Almeida,
  • João Brainer Clares de Andrade,
  • Salómon Rojas,
  • Fabiano Moulin de Moraes,
  • Viviane Cordeiro Veiga,
  • Uri Adrian Prync Flato,
  • Thiago Luiz Russo,
  • Gisele Sampaio Silva

DOI
https://doi.org/10.1055/s-0044-1788669
Journal volume & issue
Vol. 82, no. 09
pp. 001 – 008

Abstract

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Background Patients with severe coronavirus disease-19 (COVID-19) may require the use of invasive mechanical ventilation (MV) for prolonged periods. Aggressive MV parameters have been associated with changes in intracranial pressure (ICP) in patients with acute intracranial disorders. Significant ICP elevation could compromise intracranial compliance (ICC) and cerebrovascular hemodynamics (CVH). However, the effects of these parameters in individuals without neurological disorders have not yet been evaluated.

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