Nature Communications (Aug 2019)
CAF hierarchy driven by pancreatic cancer cell p53-status creates a pro-metastatic and chemoresistant environment via perlecan
- Claire Vennin,
- Pauline Mélénec,
- Romain Rouet,
- Max Nobis,
- Aurélie S. Cazet,
- Kendelle J. Murphy,
- David Herrmann,
- Daniel A. Reed,
- Morghan C. Lucas,
- Sean C. Warren,
- Zehra Elgundi,
- Mark Pinese,
- Gabriella Kalna,
- Daniel Roden,
- Monisha Samuel,
- Anaiis Zaratzian,
- Shane T. Grey,
- Andrew Da Silva,
- Wilfred Leung,
- Australian Pancreatic Genome Initiative (APGI),
- Suresh Mathivanan,
- Yingxiao Wang,
- Anthony W. Braithwaite,
- Daniel Christ,
- Ales Benda,
- Ashleigh Parkin,
- Phoebe A. Phillips,
- John M. Whitelock,
- Anthony J. Gill,
- Owen J. Sansom,
- David R. Croucher,
- Benjamin L. Parker,
- Marina Pajic,
- Jennifer P. Morton,
- Thomas R. Cox,
- Paul Timpson
Affiliations
- Claire Vennin
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Pauline Mélénec
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Romain Rouet
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Max Nobis
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Aurélie S. Cazet
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Kendelle J. Murphy
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- David Herrmann
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Daniel A. Reed
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Morghan C. Lucas
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Sean C. Warren
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Zehra Elgundi
- Graduate school of Biomedical Engineering, University of New South Wales Sydney
- Mark Pinese
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Gabriella Kalna
- Cancer Research UK Beatson Institute
- Daniel Roden
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Monisha Samuel
- Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University
- Anaiis Zaratzian
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Shane T. Grey
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Andrew Da Silva
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Wilfred Leung
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Australian Pancreatic Genome Initiative (APGI)
- Suresh Mathivanan
- Department of Physiology, Anatomy and Microbiology, School of Life Sciences, La Trobe University
- Yingxiao Wang
- Department of Bioengineering, Institute of Engineering in Medicine, University of California
- Anthony W. Braithwaite
- Children’s Medical Research Institute, University of Sydney
- Daniel Christ
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Ales Benda
- Biomedical imaging facility, Lowy Cancer Research Centre, University of New South Wales
- Ashleigh Parkin
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Phoebe A. Phillips
- Pancreatic Cancer Translational Research Group, Lowy Cancer Research Centre, School of Medical Sciences, University of New South Wales
- John M. Whitelock
- Graduate school of Biomedical Engineering, University of New South Wales Sydney
- Anthony J. Gill
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Owen J. Sansom
- Cancer Research UK Beatson Institute
- David R. Croucher
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Benjamin L. Parker
- Schools of Life and Environmental Sciences, the Charles Perkin Centre, the University of Sydney
- Marina Pajic
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Jennifer P. Morton
- Cancer Research UK Beatson Institute
- Thomas R. Cox
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- Paul Timpson
- The Garvan Institute of Medical Research & The Kinghorn Cancer Centre
- DOI
- https://doi.org/10.1038/s41467-019-10968-6
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 22
Abstract
Subtypes of cancer associated fibroblasts can both promote and suppress tumorigenesis. Here, the authors investigate how p53 status in pancreatic cancer cells affects their interaction with cancer associated fibroblasts, and report perlecan as a mediator of the pro-metastatic environment.
