Oncology Reviews (Dec 2011)

Paclitaxel induced chronic fibrosing interstitial pneumonitis: a case report and review of the literature

  • Renata Ferrarotto,
  • Guilherme Schetino,
  • Daniela Freitas,
  • Vera Capelozzi,
  • Paulo M. Hoff

DOI
https://doi.org/10.4081/oncol.2010.101
Journal volume & issue
Vol. 4, no. 2

Abstract

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Pulmonary toxicity is rarely associated with paclitaxel chemotherapy and its mechanism is not well known. This report describes one patient with pancreatic adenocarcinoma, metastatic neuroendocrine low-grade pancreatic tumor, and a concomitant stage I non-small cell lung cancer (NSCLC), who also developed life-threatening paclitaxel-induced chronic fibrosing interstitial pneumonitis. Giving the gravity of the condition and the not-wellestablished treatment, physicians should be aware of the possibility of chronic fibrosing interstitial lung disease during the course of paclitaxel containing regimens in patients who present with respiratory symptoms.

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