Cancer Management and Research (Apr 2020)
The Neutrophil to Lymphocyte and Lymphocyte to Monocyte Ratios as New Prognostic Factors in Hematological Malignancies – A Narrative Review
Abstract
Paulina Stefaniuk,1 Agnieszka Szymczyk,2 Monika Podhorecka1 1Department of Haematooncology and Bone Marrow Transplantation, Medical University of Lublin, Lublin, Poland; 2Department of Clinical Transplantology, Medical University of Lublin, Lublin, PolandCorrespondence: Agnieszka SzymczykDepartment of Clinical Transplantology, Medical University of Lublin, Chodźki 7 Street, Lublin 20-093, PolandTel +48-81 534 54 96Email [email protected]: Despite the presence of many hematological prognostic indexes, clinical course and overall survival are often highly variable even within the same patient subgroup. Recent studies suggest that simple, cost-effective, low-risk tests such as neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR) may be used to evaluate the prognosis. Their role has been well confirmed in diffuse large B-cell lymphoma (DLBCL), Hodgkin lymphoma (HL) and multiple myeloma (MM), but until now the prognostic significance of NLR and LMR in leukemias has not been widely reported. In this article, we analyze the literature data on prognostic value of NLR and LMR in haematological malignancies in the context of classic prognostic factors and clinical course.Keywords: neutrophil to lymphocyte ratio, lymphocyte to monocyte ratio, non-Hodgkin lymphoma, Hodgkin lymphoma, multiple myeloma
