Communications Biology (May 2022)
Cell response analysis in SARS-CoV-2 infected bronchial organoids
- Emi Sano,
- Tatsuya Suzuki,
- Rina Hashimoto,
- Yumi Itoh,
- Ayaka Sakamoto,
- Yusuke Sakai,
- Akatsuki Saito,
- Daisuke Okuzaki,
- Daisuke Motooka,
- Yukiko Muramoto,
- Takeshi Noda,
- Tomohiko Takasaki,
- Jun-Ichi Sakuragi,
- Shohei Minami,
- Takeshi Kobayashi,
- Takuya Yamamoto,
- Yasufumi Matsumura,
- Miki Nagao,
- Toru Okamoto,
- Kazuo Takayama
Affiliations
- Emi Sano
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Tatsuya Suzuki
- Institute for Advanced Co-Creation Studies, Research Institute for Microbial Diseases, Osaka University
- Rina Hashimoto
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Yumi Itoh
- Institute for Advanced Co-Creation Studies, Research Institute for Microbial Diseases, Osaka University
- Ayaka Sakamoto
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Yusuke Sakai
- Laboratory of Veterinary Pathology, Joint Faculty of Veterinary Medicine, Yamaguchi University
- Akatsuki Saito
- Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki
- Daisuke Okuzaki
- Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
- Daisuke Motooka
- Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University
- Yukiko Muramoto
- Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University
- Takeshi Noda
- Laboratory of Ultrastructural Virology, Institute for Frontier Life and Medical Sciences, Kyoto University
- Tomohiko Takasaki
- Kanagawa Prefectural Institute of Public Health
- Jun-Ichi Sakuragi
- Kanagawa Prefectural Institute of Public Health
- Shohei Minami
- Laboratory of Viral Replication, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita
- Takeshi Kobayashi
- Laboratory of Viral Replication, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita
- Takuya Yamamoto
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Yasufumi Matsumura
- Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University
- Miki Nagao
- Department of Clinical Laboratory Medicine, Graduate School of Medicine, Kyoto University
- Toru Okamoto
- Institute for Advanced Co-Creation Studies, Research Institute for Microbial Diseases, Osaka University
- Kazuo Takayama
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- DOI
- https://doi.org/10.1038/s42003-022-03499-2
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 9
Abstract
Bronchial organoids (BO) and BO-derived air-liquid interface models (BO-ALI) are used to model SARS-CoV-2 infection of human bronchial epithelial cells, reporting that ciliated cells were permissive to the virus, unlike basal cells.
