Genome Biology (Dec 2022)
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Stavroula Kanoni,
- Sarah E. Graham,
- Yuxuan Wang,
- Ida Surakka,
- Shweta Ramdas,
- Xiang Zhu,
- Shoa L. Clarke,
- Konain Fatima Bhatti,
- Sailaja Vedantam,
- Thomas W. Winkler,
- Adam E. Locke,
- Eirini Marouli,
- Greg J. M. Zajac,
- Kuan-Han H. Wu,
- Ioanna Ntalla,
- Qin Hui,
- Derek Klarin,
- Austin T. Hilliard,
- Zeyuan Wang,
- Chao Xue,
- Gudmar Thorleifsson,
- Anna Helgadottir,
- Daniel F. Gudbjartsson,
- Hilma Holm,
- Isleifur Olafsson,
- Mi Yeong Hwang,
- Sohee Han,
- Masato Akiyama,
- Saori Sakaue,
- Chikashi Terao,
- Masahiro Kanai,
- Wei Zhou,
- Ben M. Brumpton,
- Humaira Rasheed,
- Aki S. Havulinna,
- Yogasudha Veturi,
- Jennifer Allen Pacheco,
- Elisabeth A. Rosenthal,
- Todd Lingren,
- QiPing Feng,
- Iftikhar J. Kullo,
- Akira Narita,
- Jun Takayama,
- Hilary C. Martin,
- Karen A. Hunt,
- Bhavi Trivedi,
- Jeffrey Haessler,
- Franco Giulianini,
- Yuki Bradford,
- Jason E. Miller,
- Archie Campbell,
- Kuang Lin,
- Iona Y. Millwood,
- Asif Rasheed,
- George Hindy,
- Jessica D. Faul,
- Wei Zhao,
- David R. Weir,
- Constance Turman,
- Hongyan Huang,
- Mariaelisa Graff,
- Ananyo Choudhury,
- Dhriti Sengupta,
- Anubha Mahajan,
- Michael R. Brown,
- Weihua Zhang,
- Ketian Yu,
- Ellen M. Schmidt,
- Anita Pandit,
- Stefan Gustafsson,
- Xianyong Yin,
- Jian’an Luan,
- Jing-Hua Zhao,
- Fumihiko Matsuda,
- Hye-Mi Jang,
- Kyungheon Yoon,
- Carolina Medina-Gomez,
- Achilleas Pitsillides,
- Jouke Jan Hottenga,
- Andrew R. Wood,
- Yingji Ji,
- Zishan Gao,
- Simon Haworth,
- Noha A. Yousri,
- Ruth E. Mitchell,
- Jin Fang Chai,
- Mette Aadahl,
- Anne A. Bjerregaard,
- Jie Yao,
- Ani Manichaikul,
- Chii-Min Hwu,
- Yi-Jen Hung,
- Helen R. Warren,
- Julia Ramirez,
- Jette Bork-Jensen,
- Line L. Kårhus,
- Anuj Goel,
- Maria Sabater-Lleal,
- Raymond Noordam,
- Pala Mauro,
- Floris Matteo,
- Aaron F. McDaid,
- Pedro Marques-Vidal,
- Matthias Wielscher,
- Stella Trompet,
- Naveed Sattar,
- Line T. Møllehave,
- Matthias Munz,
- Lingyao Zeng,
- Jianfeng Huang,
- Bin Yang,
- Alaitz Poveda,
- Azra Kurbasic,
- Claudia Lamina,
- Lukas Forer,
- Markus Scholz,
- Tessel E. Galesloot,
- Jonathan P. Bradfield,
- Sanni E. Ruotsalainen,
- EWarwick Daw,
- Joseph M. Zmuda,
- Jonathan S. Mitchell,
- Christian Fuchsberger,
- Henry Christensen,
- Jennifer A. Brody,
- Miguel Vazquez-Moreno,
- Mary F. Feitosa,
- Mary K. Wojczynski,
- Zhe Wang,
- Michael H. Preuss,
- Massimo Mangino,
- Paraskevi Christofidou,
- Niek Verweij,
- Jan W. Benjamins,
- Jorgen Engmann,
- Noah L. Tsao,
- Anurag Verma,
- Roderick C. Slieker,
- Ken Sin Lo,
- Nuno R. Zilhao,
- Phuong Le,
- Marcus E. Kleber,
- Graciela E. Delgado,
- Shaofeng Huo,
- Daisuke D. Ikeda,
- Hiroyuki Iha,
- Jian Yang,
- Jun Liu,
- Ayşe Demirkan,
- Hampton L. Leonard,
- Jonathan Marten,
- Mirjam Frank,
- Börge Schmidt,
- Laura J. Smyth,
- Marisa Cañadas-Garre,
- Chaolong Wang,
- Masahiro Nakatochi,
- Andrew Wong,
- Nina Hutri-Kähönen,
- Xueling Sim,
- Rui Xia,
- Alicia Huerta-Chagoya,
- Juan Carlos Fernandez-Lopez,
- Valeriya Lyssenko,
- Suraj S. Nongmaithem,
- Swati Bayyana,
- Heather M. Stringham,
- Marguerite R. Irvin,
- Christopher Oldmeadow,
- Han-Na Kim,
- Seungho Ryu,
- Paul R. H. J. Timmers,
- Liubov Arbeeva,
- Rajkumar Dorajoo,
- Leslie A. Lange,
- Gauri Prasad,
- Laura Lorés-Motta,
- Marc Pauper,
- Jirong Long,
- Xiaohui Li,
- Elizabeth Theusch,
- Fumihiko Takeuchi,
- Cassandra N. Spracklen,
- Anu Loukola,
- Sailalitha Bollepalli,
- Sophie C. Warner,
- Ya Xing Wang,
- Wen B. Wei,
- Teresa Nutile,
- Daniela Ruggiero,
- Yun Ju Sung,
- Shufeng Chen,
- Fangchao Liu,
- Jingyun Yang,
- Katherine A. Kentistou,
- Bernhard Banas,
- Giuseppe Giovanni Nardone,
- Karina Meidtner,
- Lawrence F. Bielak,
- Jennifer A. Smith,
- Prashantha Hebbar,
- Aliki-Eleni Farmaki,
- Edith Hofer,
- Maoxuan Lin,
- Maria Pina Concas,
- Simona Vaccargiu,
- Peter J. van der Most,
- Niina Pitkänen,
- Brian E. Cade,
- Sander W. van der Laan,
- Kumaraswamy Naidu Chitrala,
- Stefan Weiss,
- Amy R. Bentley,
- Ayo P. Doumatey,
- Adebowale A. Adeyemo,
- Jong Young Lee,
- Eva R. B. Petersen,
- Aneta A. Nielsen,
- Hyeok Sun Choi,
- Maria Nethander,
- Sandra Freitag-Wolf,
- Lorraine Southam,
- Nigel W. Rayner,
- Carol A. Wang,
- Shih-Yi Lin,
- Jun-Sing Wang,
- Christian Couture,
- Leo-Pekka Lyytikäinen,
- Kjell Nikus,
- Gabriel Cuellar-Partida,
- Henrik Vestergaard,
- Bertha Hidalgo,
- Olga Giannakopoulou,
- Qiuyin Cai,
- Morgan O. Obura,
- Jessica van Setten,
- Xiaoyin Li,
- Jingjing Liang,
- Hua Tang,
- Natalie Terzikhan,
- Jae Hun Shin,
- Rebecca D. Jackson,
- Alexander P. Reiner,
- Lisa Warsinger Martin,
- Zhengming Chen,
- Liming Li,
- Takahisa Kawaguchi,
- Joachim Thiery,
- Joshua C. Bis,
- Lenore J. Launer,
- Huaixing Li,
- Mike A. Nalls,
- Olli T. Raitakari,
- Sahoko Ichihara,
- Sarah H. Wild,
- Christopher P. Nelson,
- Harry Campbell,
- Susanne Jäger,
- Toru Nabika,
- Fahd Al-Mulla,
- Harri Niinikoski,
- Peter S. Braund,
- Ivana Kolcic,
- Peter Kovacs,
- Tota Giardoglou,
- Tomohiro Katsuya,
- Dominique de Kleijn,
- Gert J. de Borst,
- Eung Kweon Kim,
- Hieab H. H. Adams,
- M. Arfan Ikram,
- Xiaofeng Zhu,
- Folkert W. Asselbergs,
- Adriaan O. Kraaijeveld,
- Joline W. J. Beulens,
- Xiao-Ou Shu,
- Loukianos S. Rallidis,
- Oluf Pedersen,
- Torben Hansen,
- Paul Mitchell,
- Alex W. Hewitt,
- Mika Kähönen,
- Louis Pérusse,
- Claude Bouchard,
- Anke Tönjes,
- Yii-Der Ida Chen,
- Craig E. Pennell,
- Trevor A. Mori,
- Wolfgang Lieb,
- Andre Franke,
- Claes Ohlsson,
- Dan Mellström,
- Yoon Shin Cho,
- Hyejin Lee,
- Jian-Min Yuan,
- Woon-Puay Koh,
- Sang Youl Rhee,
- Jeong-Taek Woo,
- Iris M. Heid,
- Klaus J. Stark,
- Martina E. Zimmermann,
- Henry Völzke,
- Georg Homuth,
- Michele K. Evans,
- Alan B. Zonderman,
- Ozren Polasek,
- Gerard Pasterkamp,
- Imo E. Hoefer,
- Susan Redline,
- Katja Pahkala,
- Albertine J. Oldehinkel,
- Harold Snieder,
- Ginevra Biino,
- Reinhold Schmidt,
- Helena Schmidt,
- Stefania Bandinelli,
- George Dedoussis,
- Thangavel Alphonse Thanaraj,
- Sharon L. R. Kardia,
- Patricia A. Peyser,
- Norihiro Kato,
- Matthias B. Schulze,
- Giorgia Girotto,
- Carsten A. Böger,
- Bettina Jung,
- Peter K. Joshi,
- David A. Bennett,
- Philip L. De Jager,
- Xiangfeng Lu,
- Vasiliki Mamakou,
- Morris Brown,
- Mark J. Caulfield,
- Patricia B. Munroe,
- Xiuqing Guo,
- Marina Ciullo,
- Jost B. Jonas,
- Nilesh J. Samani,
- Jaakko Kaprio,
- Päivi Pajukanta,
- Teresa Tusié-Luna,
- Carlos A. Aguilar-Salinas,
- Linda S. Adair,
- Sonny Augustin Bechayda,
- H. Janaka de Silva,
- Ananda R. Wickremasinghe,
- Ronald M. Krauss,
- Jer-Yuarn Wu,
- Wei Zheng,
- Anneke Iden Hollander,
- Dwaipayan Bharadwaj,
- Adolfo Correa,
- James G. Wilson,
- Lars Lind,
- Chew-Kiat Heng,
- Amanda E. Nelson,
- Yvonne M. Golightly,
- James F. Wilson,
- Brenda Penninx,
- Hyung-Lae Kim,
- John Attia,
- Rodney J. Scott,
- D. C. Rao,
- Donna K. Arnett,
- Steven C. Hunt,
- Mark Walker,
- Heikki A. Koistinen,
- Giriraj R. Chandak,
- Josep M. Mercader,
- Maria C. Costanzo,
- Dongkeun Jang,
- Noël P. Burtt,
- Clicerio Gonzalez Villalpando,
- Lorena Orozco,
- Myriam Fornage,
- EShyong Tai,
- Rob M. van Dam,
- Terho Lehtimäki,
- Nish Chaturvedi,
- Mitsuhiro Yokota,
- Jianjun Liu,
- Dermot F. Reilly,
- Amy Jayne McKnight,
- Frank Kee,
- Karl-Heinz Jöckel,
- Mark I. McCarthy,
- Colin N. A. Palmer,
- Veronique Vitart,
- Caroline Hayward,
- Eleanor Simonsick,
- Cornelia M. van Duijn,
- Zi-Bing Jin,
- Jia Qu,
- Haretsugu Hishigaki,
- Xu Lin,
- Winfried März,
- Vilmundur Gudnason,
- Jean-Claude Tardif,
- Guillaume Lettre,
- Leen M.‘t Hart,
- Petra J. M. Elders,
- Scott M. Damrauer,
- Meena Kumari,
- Mika Kivimaki,
- Pim van der Harst,
- Tim D. Spector,
- Ruth J. F. Loos,
- Michael A. Province,
- Esteban J. Parra,
- Miguel Cruz,
- Bruce M. Psaty,
- Ivan Brandslund,
- Peter P. Pramstaller,
- Charles N. Rotimi,
- Kaare Christensen,
- Samuli Ripatti,
- Elisabeth Widén,
- Hakon Hakonarson,
- Struan F. A. Grant,
- Lambertus A. L. M. Kiemeney,
- Jacqueline de Graaf,
- Markus Loeffler,
- Florian Kronenberg,
- Dongfeng Gu,
- Jeanette Erdmann,
- Heribert Schunkert,
- Paul W. Franks,
- Allan Linneberg,
- J. Wouter Jukema,
- Amit V. Khera,
- Minna Männikkö,
- Marjo-Riitta Jarvelin,
- Zoltan Kutalik,
- Cucca Francesco,
- Dennis O. Mook-Kanamori,
- Ko Willems van Dijk,
- Hugh Watkins,
- David P. Strachan,
- Niels Grarup,
- Peter Sever,
- Neil Poulter,
- Lee-Ming Chuang,
- Jerome I. Rotter,
- Thomas M. Dantoft,
- Fredrik Karpe,
- Matt J. Neville,
- Nicholas J. Timpson,
- Ching-Yu Cheng,
- Tien-Yin Wong,
- Chiea Chuen Khor,
- Hengtong Li,
- Charumathi Sabanayagam,
- Annette Peters,
- Christian Gieger,
- Andrew T. Hattersley,
- Nancy L. Pedersen,
- Patrik K. E. Magnusson,
- Dorret I. Boomsma,
- Allegonda H. M. Willemsen,
- LAdrienne Cupples,
- Joyce B. J. van Meurs,
- Mohsen Ghanbari,
- Penny Gordon-Larsen,
- Wei Huang,
- Young Jin Kim,
- Yasuharu Tabara,
- Nicholas J. Wareham,
- Claudia Langenberg,
- Eleftheria Zeggini,
- Johanna Kuusisto,
- Markku Laakso,
- Erik Ingelsson,
- Goncalo Abecasis,
- John C. Chambers,
- Jaspal S. Kooner,
- Paul S. de Vries,
- Alanna C. Morrison,
- Scott Hazelhurst,
- Michèle Ramsay,
- Kari E. North,
- Martha Daviglus,
- Peter Kraft,
- Nicholas G. Martin,
- John B. Whitfield,
- Shahid Abbas,
- Danish Saleheen,
- Robin G. Walters,
- Michael V. Holmes,
- Corri Black,
- Blair H. Smith,
- Aris Baras,
- Anne E. Justice,
- Julie E. Buring,
- Paul M. Ridker,
- Daniel I. Chasman,
- Charles Kooperberg,
- Gen Tamiya,
- Masayuki Yamamoto,
- David A. van Heel,
- Richard C. Trembath,
- Wei-Qi Wei,
- Gail P. Jarvik,
- Bahram Namjou,
- M. Geoffrey Hayes,
- Marylyn D. Ritchie,
- Pekka Jousilahti,
- Veikko Salomaa,
- Kristian Hveem,
- Bjørn Olav Åsvold,
- Michiaki Kubo,
- Yoichiro Kamatani,
- Yukinori Okada,
- Yoshinori Murakami,
- Bong-Jo Kim,
- Unnur Thorsteinsdottir,
- Kari Stefansson,
- Jifeng Zhang,
- YEugene Chen,
- Yuk-Lam Ho,
- Julie A. Lynch,
- Daniel J. Rader,
- Philip S. Tsao,
- Kyong-Mi Chang,
- Kelly Cho,
- Christopher J. O’Donnell,
- John M. Gaziano,
- Peter W. F. Wilson,
- Timothy M. Frayling,
- Joel N. Hirschhorn,
- Sekar Kathiresan,
- Karen L. Mohlke,
- Yan V. Sun,
- Andrew P. Morris,
- Michael Boehnke,
- Christopher D. Brown,
- Pradeep Natarajan,
- Panos Deloukas,
- Cristen J. Willer,
- Themistocles L. Assimes,
- Gina M. Peloso
Affiliations
- Stavroula Kanoni
- William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Sarah E. Graham
- Department of Internal Medicine, Division of Cardiology, University of Michigan
- Yuxuan Wang
- Department of Biostatistics, Boston University School of Public Health
- Ida Surakka
- Department of Internal Medicine, Division of Cardiology, University of Michigan
- Shweta Ramdas
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Xiang Zhu
- Department of Statistics, The Pennsylvania State University
- Shoa L. Clarke
- VA Palo Alto Health Care Systems
- Konain Fatima Bhatti
- William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Sailaja Vedantam
- Boston Children’s Hospital
- Thomas W. Winkler
- Department of Genetic Epidemiology, University of Regensburg
- Adam E. Locke
- McDonnell Genome Institute and Department of Medicine, Washington University
- Eirini Marouli
- William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Greg J. M. Zajac
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Kuan-Han H. Wu
- Department of Computational Medicine and Bioinformatics, University of Michigan
- Ioanna Ntalla
- Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Qin Hui
- Department of Epidemiology, Emory University Rollins School of Public Health
- Derek Klarin
- VA Palo Alto Health Care Systems
- Austin T. Hilliard
- VA Palo Alto Health Care Systems
- Zeyuan Wang
- Department of Epidemiology, Emory University Rollins School of Public Health
- Chao Xue
- Department of Internal Medicine, Division of Cardiology, University of Michigan
- Gudmar Thorleifsson
- deCODE Genetics/Amgen
- Anna Helgadottir
- deCODE Genetics/Amgen
- Daniel F. Gudbjartsson
- deCODE Genetics/Amgen
- Hilma Holm
- deCODE Genetics/Amgen
- Isleifur Olafsson
- Department of Clinical Biochemistry, Landspitali - National University Hospital of Iceland
- Mi Yeong Hwang
- Division of Genome Science, Department of Precision Medicine, National Institute of Health
- Sohee Han
- Division of Genome Science, Department of Precision Medicine, National Institute of Health
- Masato Akiyama
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Saori Sakaue
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Chikashi Terao
- Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences
- Masahiro Kanai
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Wei Zhou
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Ben M. Brumpton
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Humaira Rasheed
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Aki S. Havulinna
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Yogasudha Veturi
- Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine
- Jennifer Allen Pacheco
- Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine
- Elisabeth A. Rosenthal
- Department of Medicine (Medical Genetics), University of Washington
- Todd Lingren
- Division of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center
- QiPing Feng
- Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center
- Iftikhar J. Kullo
- Department of Cardiovascular Medicine and the Gonda Vascular Center, Mayo Clinic
- Akira Narita
- Tohoku Medical Megabank Organization, Tohoku University
- Jun Takayama
- Tohoku Medical Megabank Organization, Tohoku University
- Hilary C. Martin
- Wellcome Trust Sanger Institute
- Karen A. Hunt
- Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Bhavi Trivedi
- Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Jeffrey Haessler
- Fred Hutchinson Cancer Center, Division of Public Health Sciences
- Franco Giulianini
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Yuki Bradford
- Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine
- Jason E. Miller
- Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine
- Archie Campbell
- Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital
- Kuang Lin
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Iona Y. Millwood
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Asif Rasheed
- Center for Non-Communicable Diseases
- George Hindy
- Department of Population Medicine, Qatar University College of Medicine, QU Health
- Jessica D. Faul
- Survey Research Center, Institute for Social Research, University of Michigan
- Wei Zhao
- Survey Research Center, Institute for Social Research, University of Michigan
- David R. Weir
- Survey Research Center, Institute for Social Research, University of Michigan
- Constance Turman
- Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Hongyan Huang
- Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Mariaelisa Graff
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Ananyo Choudhury
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Dhriti Sengupta
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Anubha Mahajan
- Wellcome Centre for Human Genetics, University of Oxford
- Michael R. Brown
- Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston
- Weihua Zhang
- Department of Epidemiology and Biostatistics, Imperial College London
- Ketian Yu
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Ellen M. Schmidt
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Anita Pandit
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Stefan Gustafsson
- Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University
- Xianyong Yin
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Jian’an Luan
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Jing-Hua Zhao
- Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort’s Causeway
- Fumihiko Matsuda
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Hye-Mi Jang
- Division of Genome Science, Department of Precision Medicine, National Institute of Health
- Kyungheon Yoon
- Division of Genome Science, Department of Precision Medicine, National Institute of Health
- Carolina Medina-Gomez
- Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam
- Achilleas Pitsillides
- Department of Biostatistics, Boston University School of Public Health
- Jouke Jan Hottenga
- Department of Biological Psychology, Vrije Universiteit Amsterdam
- Andrew R. Wood
- Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
- Yingji Ji
- Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
- Zishan Gao
- Nanjing University of Chinese Medicine
- Simon Haworth
- MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove
- Noha A. Yousri
- Department of Genetic Medicine, Weill Cornell Medicine-Qatar
- Ruth E. Mitchell
- MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove
- Jin Fang Chai
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Mette Aadahl
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital
- Anne A. Bjerregaard
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital
- Jie Yao
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center
- Ani Manichaikul
- Center for Public Health Genomics, University of Virginia
- Chii-Min Hwu
- Section of Endocrinology and Metabolism, Department of Medicine, Taipei Veterans General Hospital
- Yi-Jen Hung
- Institute of Preventive Medicine, National Defense Medical Center
- Helen R. Warren
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Julia Ramirez
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Jette Bork-Jensen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Line L. Kårhus
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital
- Anuj Goel
- Wellcome Centre for Human Genetics, University of Oxford
- Maria Sabater-Lleal
- Unit of Genomics of Complex Diseases, Institut d’Investigació Biomèdica Sant Pau (IIB SANT PAU)
- Raymond Noordam
- Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center
- Pala Mauro
- Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche
- Floris Matteo
- Istituto Di Ricerca Genetica E Biomedica, Consiglio Nazionale Delle Ricerche
- Aaron F. McDaid
- University Center for Primary Care and Public Health, University of Lausanne
- Pedro Marques-Vidal
- Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne
- Matthias Wielscher
- Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
- Stella Trompet
- Department of Cardiology, Leiden University Medical Center
- Naveed Sattar
- BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine
- Line T. Møllehave
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital
- Matthias Munz
- Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, University Heart Center Lübeck, Lübeck and Charité – University Medicine Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin and Berlin Institute of Health, Institute for Dental and Craniofacial Sciences, Department of Periodontology and Synoptic Dentistry
- Lingyao Zeng
- Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München
- Jianfeng Huang
- Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
- Bin Yang
- Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
- Alaitz Poveda
- Lund University Diabetes Center, Lund University
- Azra Kurbasic
- Lund University Diabetes Center, Lund University
- Claudia Lamina
- Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck
- Lukas Forer
- Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck
- Markus Scholz
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Tessel E. Galesloot
- Radboud University Medical Center, Radboud Institute for Health Sciences
- Jonathan P. Bradfield
- Quantinuum Research LLC
- Sanni E. Ruotsalainen
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- EWarwick Daw
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Joseph M. Zmuda
- Department of Epidemiology, University of Pittsburgh
- Jonathan S. Mitchell
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Christian Fuchsberger
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Henry Christensen
- Department of Clinical Biochemistry, Lillebaelt Hospital
- Jennifer A. Brody
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Miguel Vazquez-Moreno
- Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social
- Mary F. Feitosa
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Mary K. Wojczynski
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Zhe Wang
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Michael H. Preuss
- The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- Massimo Mangino
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Paraskevi Christofidou
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Niek Verweij
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Jan W. Benjamins
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Jorgen Engmann
- Institute of Cardiovascular Sciences, University College London
- Noah L. Tsao
- Department of Surgery, University of Pennsylvania
- Anurag Verma
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Roderick C. Slieker
- Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute
- Ken Sin Lo
- Montreal Heart Institute, Université de Montréal
- Nuno R. Zilhao
- Icelandic Heart Association
- Phuong Le
- Department of Anthropology, University of Toronto at Mississauga
- Marcus E. Kleber
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Graciela E. Delgado
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Shaofeng Huo
- Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Daisuke D. Ikeda
- Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd
- Hiroyuki Iha
- Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd
- Jian Yang
- School of Life Sciences, Westlake University
- Jun Liu
- Nuffield Department of Population Health, University of Oxford
- Ayşe Demirkan
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Hampton L. Leonard
- Laboratory of Neurogenetics, National Institute On Aging, NIH
- Jonathan Marten
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital
- Mirjam Frank
- Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen
- Börge Schmidt
- Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen
- Laura J. Smyth
- Centre for Public Health, Queen’s University of Belfast
- Marisa Cañadas-Garre
- Centre for Public Health, Queen’s University of Belfast
- Chaolong Wang
- Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology
- Masahiro Nakatochi
- Public Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine
- Andrew Wong
- MRC Unit for Lifelong Health and Ageing at UCL
- Nina Hutri-Kähönen
- Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University
- Xueling Sim
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Rui Xia
- Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston
- Alicia Huerta-Chagoya
- CONACYT, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán
- Juan Carlos Fernandez-Lopez
- Departamento de Genómica Computacional, Instituto Nacional de Medicina Genómica
- Valeriya Lyssenko
- Lund University Diabetes Center, Lund University
- Suraj S. Nongmaithem
- Academy of Scientific and Innovative Research (AcSIR)
- Swati Bayyana
- Genomic Research On Complex Diseases (GRC Group), CSIR-Centre for Cellular and Molecular Biology
- Heather M. Stringham
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Marguerite R. Irvin
- Epidemiology, School of Public Health, University of Alabama at Birmingham
- Christopher Oldmeadow
- Hunter Medical Research Institute
- Han-Na Kim
- Medical Research Institute, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine
- Seungho Ryu
- Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine
- Paul R. H. J. Timmers
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital
- Liubov Arbeeva
- Thurston Arthritis Research Center, University of North Carolina
- Rajkumar Dorajoo
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Leslie A. Lange
- Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, Anschutz Medical Campus, University of Colorado
- Gauri Prasad
- Genomics and Molecular Medicine Unit, CSIR-Institute of Genomics and Integrative Biology
- Laura Lorés-Motta
- Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15
- Marc Pauper
- Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15
- Jirong Long
- Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center
- Xiaohui Li
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center
- Elizabeth Theusch
- Department of Pediatrics, University of California San Francisco
- Fumihiko Takeuchi
- National Center for Global Health and Medicine
- Cassandra N. Spracklen
- Department of Genetics, University of North Carolina
- Anu Loukola
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Sailalitha Bollepalli
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Sophie C. Warner
- Department of Cardiovascular Sciences, University of Leicester
- Ya Xing Wang
- Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
- Wen B. Wei
- Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
- Teresa Nutile
- Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR
- Daniela Ruggiero
- Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR
- Yun Ju Sung
- Division of Biostatistics, Washington University
- Shufeng Chen
- Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
- Fangchao Liu
- Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
- Jingyun Yang
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Katherine A. Kentistou
- Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place
- Bernhard Banas
- Dept of Nephrology, University Hospital Regensburg
- Giuseppe Giovanni Nardone
- Institute for Maternal and Child Health, IRCCS Burlo Garofolo
- Karina Meidtner
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
- Lawrence F. Bielak
- Department of Epidemiology, School of Public Health, University of Michigan
- Jennifer A. Smith
- Survey Research Center, Institute for Social Research, University of Michigan
- Prashantha Hebbar
- Department of Genetics and Bioinformatics, Dasman Diabetes Institute
- Aliki-Eleni Farmaki
- Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens
- Edith Hofer
- Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz
- Maoxuan Lin
- Massachusetts General Hospital Cancer Center
- Maria Pina Concas
- Institute for Maternal and Child Health, IRCCS Burlo Garofolo
- Simona Vaccargiu
- Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari
- Peter J. van der Most
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Niina Pitkänen
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Brian E. Cade
- Sleep Medicine and Circadian Disorders, Brigham and Women’s Hospital
- Sander W. van der Laan
- Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University
- Kumaraswamy Naidu Chitrala
- Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH
- Stefan Weiss
- Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald
- Amy R. Bentley
- Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Ayo P. Doumatey
- Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Adebowale A. Adeyemo
- Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Jong Young Lee
- Eva R. B. Petersen
- Department of Clinical Biochemistry and Immunology, Hospital of Southern Jutland
- Aneta A. Nielsen
- Department of Clinical Biochemistry, Lillebaelt Hospital
- Hyeok Sun Choi
- Department of Biomedical Science, Hallym University
- Maria Nethander
- Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Sandra Freitag-Wolf
- Institute of Medical Informatics and Statistics, Kiel University
- Lorraine Southam
- Wellcome Trust Sanger Institute
- Nigel W. Rayner
- Wellcome Trust Sanger Institute
- Carol A. Wang
- School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle
- Shih-Yi Lin
- Center for Geriatrics and Gerontology, Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital
- Jun-Sing Wang
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital
- Christian Couture
- Department of Kinesiology, Université Laval
- Leo-Pekka Lyytikäinen
- Department of Clinical Chemistry, Fimlab Laboratories
- Kjell Nikus
- Department of Cardiology, Heart Center, Tampere University Hospital
- Gabriel Cuellar-Partida
- University of Queensland Diamantina Institute, Translational Research Institute, Kent St
- Henrik Vestergaard
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Bertha Hidalgo
- Department of Epidemiology, Ryals School of Public Health, University of Alabama at Birmingham
- Olga Giannakopoulou
- William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Qiuyin Cai
- Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center
- Morgan O. Obura
- Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute
- Jessica van Setten
- Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University
- Xiaoyin Li
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Jingjing Liang
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Hua Tang
- Department of Genetics, Stanford University School of Medicine Stanford
- Natalie Terzikhan
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Jae Hun Shin
- Department of Biomedical Science, Hallym University
- Rebecca D. Jackson
- Division of Endocrinology, Ohio State University
- Alexander P. Reiner
- Department of Epidemiology, University of Washington
- Lisa Warsinger Martin
- School of Medicine and Health Sciences, George Washington University
- Zhengming Chen
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Liming Li
- Department of Epidemiology, School of Public Health, Peking University Health Science Center
- Takahisa Kawaguchi
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Joachim Thiery
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Joshua C. Bis
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Lenore J. Launer
- Laboratory of Epidemiology and Population Sciences, National Institute On Aging, NIH
- Huaixing Li
- Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Mike A. Nalls
- Center for Alzheimer’s and Related Dementias, NIH
- Olli T. Raitakari
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Sahoko Ichihara
- Department of Environmental and Preventive Medicine, Jichi Medical University School of Medicine
- Sarah H. Wild
- Centre for Population Health Sciences, Usher Institute, University of Edinburgh, Teviot Place
- Christopher P. Nelson
- Department of Cardiovascular Sciences, University of Leicester
- Harry Campbell
- Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place
- Susanne Jäger
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
- Toru Nabika
- Department of Functional Pathology, Shimane University School of Medicine
- Fahd Al-Mulla
- Department of Genetics and Bioinformatics, Dasman Diabetes Institute
- Harri Niinikoski
- Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku
- Peter S. Braund
- Department of Cardiovascular Sciences, University of Leicester
- Ivana Kolcic
- University of Split School of Medicine
- Peter Kovacs
- University of Leipzig Medical Center
- Tota Giardoglou
- Department of Nutrition-Dietetics, Harokopio University
- Tomohiro Katsuya
- Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine
- Dominique de Kleijn
- Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University
- Gert J. de Borst
- Department of Vascular Surgery, Division of Surgical Specialties, University Medical Center Utrecht, Utrecht University
- Eung Kweon Kim
- Corneal Dystrophy Research Institute, Yonsei University College of Medicine, Saevit Eye Hospital
- Hieab H. H. Adams
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- M. Arfan Ikram
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Xiaofeng Zhu
- Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Folkert W. Asselbergs
- Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University
- Adriaan O. Kraaijeveld
- Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht University
- Joline W. J. Beulens
- Amsterdam UMC, Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute
- Xiao-Ou Shu
- Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center
- Loukianos S. Rallidis
- Second Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Attikon University Hospital
- Oluf Pedersen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Torben Hansen
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Paul Mitchell
- Center for Vision Research, Department of Ophthalmology and The Westmead Institute, University of Sydney
- Alex W. Hewitt
- School of Medicine, Menzies Institute for Medical Research, University of Tasmania
- Mika Kähönen
- Department of Clinical Physiology, Tampere University Hospital
- Louis Pérusse
- Department of Kinesiology, Université Laval
- Claude Bouchard
- Pennington Biomedical Research Center
- Anke Tönjes
- University of Leipzig Medical Center
- Yii-Der Ida Chen
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center
- Craig E. Pennell
- School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle
- Trevor A. Mori
- Discipline of Internal Medicine, Medical School, The University of Western Australia
- Wolfgang Lieb
- Institute of Epidemiology, Kiel University
- Andre Franke
- Institute of Clinical Molecular Biology, Kiel University
- Claes Ohlsson
- Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Dan Mellström
- Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg
- Yoon Shin Cho
- Department of Biomedical Science, Hallym University
- Hyejin Lee
- Department of Internal Medicine, EwhaWomans University School of Medicine
- Jian-Min Yuan
- Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh
- Woon-Puay Koh
- Healthy Longevity Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore
- Sang Youl Rhee
- Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine
- Jeong-Taek Woo
- Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine
- Iris M. Heid
- Department of Genetic Epidemiology, University of Regensburg
- Klaus J. Stark
- Department of Genetic Epidemiology, University of Regensburg
- Martina E. Zimmermann
- Department of Genetic Epidemiology, University of Regensburg
- Henry Völzke
- Institute for Community Medicine, University Medicine Greifswald
- Georg Homuth
- Interfaculty Institute for Genetics and Functional Genomics, Department of Functional Genomics, University of Greifswald and University Medicine Greifswald
- Michele K. Evans
- Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center
- Alan B. Zonderman
- Laboratory of Epidemiology and Population Science, National Institute On Aging Intramural Research Program, NIH Biomedical Research Center
- Ozren Polasek
- University of Split School of Medicine
- Gerard Pasterkamp
- Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University
- Imo E. Hoefer
- Central Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics, University Medical Center Utrecht, Utrecht University
- Susan Redline
- Sleep Medicine and Circadian Disorders, Brigham and Women’s Hospital
- Katja Pahkala
- Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku
- Albertine J. Oldehinkel
- Interdisciplinary Center Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen
- Harold Snieder
- Department of Epidemiology, University of Groningen, University Medical Center Groningen
- Ginevra Biino
- Institute of Molecular Genetics, National Research Council of Italy
- Reinhold Schmidt
- Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz
- Helena Schmidt
- Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz
- Stefania Bandinelli
- Local Health Unit Toscana Centro
- George Dedoussis
- Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University of Athens
- Thangavel Alphonse Thanaraj
- Department of Genetics and Bioinformatics, Dasman Diabetes Institute
- Sharon L. R. Kardia
- Department of Epidemiology, School of Public Health, University of Michigan
- Patricia A. Peyser
- Department of Epidemiology, School of Public Health, University of Michigan
- Norihiro Kato
- National Center for Global Health and Medicine
- Matthias B. Schulze
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke
- Giorgia Girotto
- Institute for Maternal and Child Health, IRCCS Burlo Garofolo
- Carsten A. Böger
- Dept of Nephrology, University Hospital Regensburg
- Bettina Jung
- Dept of Nephrology, University Hospital Regensburg
- Peter K. Joshi
- Centre for Global Health Research, Usher Institute, University of Edinburgh, Teviot Place
- David A. Bennett
- Rush Alzheimer’s Disease Center, Rush University Medical Center
- Philip L. De Jager
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Xiangfeng Lu
- Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
- Vasiliki Mamakou
- Medical School, National and Kapodistrian University Athens
- Morris Brown
- NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London
- Mark J. Caulfield
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Patricia B. Munroe
- William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, John Vane Science Centre, Charterhouse Square
- Xiuqing Guo
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center
- Marina Ciullo
- Institute of Genetics and Biophysics “Adriano Buzzati-Traverso” - CNR
- Jost B. Jonas
- Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University
- Nilesh J. Samani
- Department of Cardiovascular Sciences, University of Leicester
- Jaakko Kaprio
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Päivi Pajukanta
- Department of Human Genetics, David Geffen School of Medicine at UCLA, University of California
- Teresa Tusié-Luna
- Unidad de Biología Molecular Y Medicina Genómica, Instituto de Investigaciones Biomédicas UNAM/ Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán
- Carlos A. Aguilar-Salinas
- Departamento de Endocrinología Y Metabolismo, Instituto Nacional de Ciencias Médicas Y Nutrición Salvador Zubirán
- Linda S. Adair
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina
- Sonny Augustin Bechayda
- USC–Office of Population Studies Foundation, University of San Carlos
- H. Janaka de Silva
- Department of Medicine, Faculty of Medicine, University of Kelaniya
- Ananda R. Wickremasinghe
- Department of Public Health, Faculty of Medicine, University of Kelaniya
- Ronald M. Krauss
- Children’s Hospital Oakland Research Institute
- Jer-Yuarn Wu
- Institute of Biomedical Sciences, Academia Sinica
- Wei Zheng
- Vanderbilt Epidemiology Center, Division of Epidemiology, Vanderbilt University Medical Center
- Anneke Iden Hollander
- Departments of Ophthalmology and Human Genetics, Radboud University Nijmegen Medical Center, Philips Van Leydenlaan 15
- Dwaipayan Bharadwaj
- Academy of Scientific and Innovative Research, CSIR-Human Resource Development Centre
- Adolfo Correa
- Department of Medicine, University of Mississippi Medical Center
- James G. Wilson
- Department of Physiology and Biophysics, University of Mississippi Medical Center
- Lars Lind
- Department of Medical Sciences, Uppsala University
- Chew-Kiat Heng
- Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore and Khoo Teck Puat - National University Children’s Medical Institute, National University Health System
- Amanda E. Nelson
- Thurston Arthritis Research Center, University of North Carolina
- Yvonne M. Golightly
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- James F. Wilson
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital
- Brenda Penninx
- Amsterdam Public Health Research Institute
- Hyung-Lae Kim
- Department of Biochemistry, College of Medicine, Ewha Womans University
- John Attia
- Hunter Medical Research Institute
- Rodney J. Scott
- Hunter Medical Research Institute
- D. C. Rao
- Division of Biostatistics, Washington University School of Medicine
- Donna K. Arnett
- Office of the Provost, University of South Carolina
- Steven C. Hunt
- Department of Genetic Medicine, Weill Cornell Medicine-Qatar
- Mark Walker
- Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University
- Heikki A. Koistinen
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare
- Giriraj R. Chandak
- Academy of Scientific and Innovative Research (AcSIR)
- Josep M. Mercader
- Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard
- Maria C. Costanzo
- Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard
- Dongkeun Jang
- Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard
- Noël P. Burtt
- Programs in Metabolism and Medical and Population Genetics, Broad Institute of MIT and Harvard
- Clicerio Gonzalez Villalpando
- InstitutoNacional de Salud Publica Y Centro de Estudios en Diabetes
- Lorena Orozco
- Laboratorio de Inmunogenómica Y Enfermedades Metabólicas, Instituto Nacional de Medicina Genómica
- Myriam Fornage
- Brown Foundation Institute of Molecular Medicine, McGovern Medical School, University of Texas Health Science Center at Houston
- EShyong Tai
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Rob M. van Dam
- Saw Swee Hock School of Public Health, National University of Singapore and National University Health System
- Terho Lehtimäki
- Department of Clinical Chemistry, Fimlab Laboratories
- Nish Chaturvedi
- MRC Unit for Lifelong Health and Ageing at UCL
- Mitsuhiro Yokota
- Kurume University School of Medicine
- Jianjun Liu
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Dermot F. Reilly
- Genetics, Merck Sharp & Dohme Corp.
- Amy Jayne McKnight
- Centre for Public Health, Queen’s University of Belfast
- Frank Kee
- Centre for Public Health, Queen’s University of Belfast
- Karl-Heinz Jöckel
- Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen
- Mark I. McCarthy
- Wellcome Centre for Human Genetics, University of Oxford
- Colin N. A. Palmer
- Population Health and Genomics, University of Dundee, Ninwells Hospital and Medical School
- Veronique Vitart
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital
- Caroline Hayward
- MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital
- Eleanor Simonsick
- Intramural Research Program, National Institute On Aging, 3001 S. Hanover St.
- Cornelia M. van Duijn
- Nuffield Department of Population Health, University of Oxford
- Zi-Bing Jin
- Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory
- Jia Qu
- The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University
- Haretsugu Hishigaki
- Biomedical Technology Research Center, Tokushima Research Institute, Otsuka Pharmaceutical Co., Ltd
- Xu Lin
- Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences
- Winfried März
- Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University
- Vilmundur Gudnason
- Icelandic Heart Association
- Jean-Claude Tardif
- Montreal Heart Institute, Université de Montréal
- Guillaume Lettre
- Montreal Heart Institute, Université de Montréal
- Leen M.‘t Hart
- Department of Cell and Chemical Biology, Leiden University Medical Center
- Petra J. M. Elders
- Department of General Practice, Amsterdam UMC
- Scott M. Damrauer
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Meena Kumari
- Institute of Social and Economic Research, University of Essex
- Mika Kivimaki
- Department of Epidemiology and Public Health, University College London
- Pim van der Harst
- Department of Cardiology, University of Groningen, University Medical Center Groningen
- Tim D. Spector
- Department of Twin Research and Genetic Epidemiology, King’s College London
- Ruth J. F. Loos
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Michael A. Province
- Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine
- Esteban J. Parra
- Department of Anthropology, University of Toronto at Mississauga
- Miguel Cruz
- Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social
- Bruce M. Psaty
- Cardiovascular Health Research Unit, Department of Medicine, University of Washington
- Ivan Brandslund
- Department of Clinical Biochemistry, Lillebaelt Hospital
- Peter P. Pramstaller
- Institute for Biomedicine, Eurac Research, Affiliated Institute of the University of Lübeck
- Charles N. Rotimi
- Center for Research On Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health
- Kaare Christensen
- Danish Aging Research Center, University of Southern Denmark
- Samuli Ripatti
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Elisabeth Widén
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki
- Hakon Hakonarson
- Center for Applied Genomics, Children’s Hospital of Philadelphia
- Struan F. A. Grant
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Lambertus A. L. M. Kiemeney
- Radboud University Medical Center, Radboud Institute for Health Sciences
- Jacqueline de Graaf
- Radboud University Medical Center, Radboud Institute for Health Sciences
- Markus Loeffler
- Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig
- Florian Kronenberg
- Institute of Genetic Epidemiology, Department of Genetics, Medical University of Innsbruck
- Dongfeng Gu
- Key Laboratory of Cardiovascular Epidemiology and Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College
- Jeanette Erdmann
- Institute for Cardiogenetics, University of Lübeck, DZHK (German Research Centre for Cardiovascular Research), Partner Site Hamburg/Lübeck/Kiel, and University Heart Center Lübeck
- Heribert Schunkert
- Deutsches Herzzentrum München, Klinik Für Herz- Und Kreislauferkrankungen, Technische Universität München
- Paul W. Franks
- Lund University Diabetes Center, Lund University
- Allan Linneberg
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital
- J. Wouter Jukema
- Department of Cardiology, Leiden University Medical Center
- Amit V. Khera
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Minna Männikkö
- Northern Finland Birth Cohorts, Infrastructure for Population Studies, Faculty of Medicine, University of Oulu
- Marjo-Riitta Jarvelin
- Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London
- Zoltan Kutalik
- University Center for Primary Care and Public Health, University of Lausanne
- Cucca Francesco
- Institute for Genetic and Biomedical Research, Italian National Council of Research (IRGB CNR)
- Dennis O. Mook-Kanamori
- Department of Clinical Epidemiology, Leiden University Medical Center
- Ko Willems van Dijk
- Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center
- Hugh Watkins
- Wellcome Centre for Human Genetics, University of Oxford
- David P. Strachan
- Population Health Research Institute, St George’s, University of London
- Niels Grarup
- Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- Peter Sever
- National Heart and Lung Institute, Imperial College London
- Neil Poulter
- School of Public Health, Imperial College London
- Lee-Ming Chuang
- Department of Internal Medicine, National Taiwan University Hospital
- Jerome I. Rotter
- The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Lundquist Institute for Biomedical Innovations (Formerly LABioMed) at Harbor-UCLA Medical Center
- Thomas M. Dantoft
- Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital
- Fredrik Karpe
- OCDEM, University of Oxford, Churchill Hospital
- Matt J. Neville
- OCDEM, University of Oxford, Churchill Hospital
- Nicholas J. Timpson
- MRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Oakfield House, Oakfield Grove
- Ching-Yu Cheng
- Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre
- Tien-Yin Wong
- Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre
- Chiea Chuen Khor
- Genome Institute of Singapore, Agency for Science, Technology and Research
- Hengtong Li
- Data Science, Singapore Eye Research Institute, Singapore National Eye Centre
- Charumathi Sabanayagam
- Ocular Epidemiology, Singapore Eye Research Institute, Singapore National Eye Centre
- Annette Peters
- Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Christian Gieger
- Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health
- Andrew T. Hattersley
- Medical School, University of Exeter, University of Exeter
- Nancy L. Pedersen
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Patrik K. E. Magnusson
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet
- Dorret I. Boomsma
- Department of Biological Psychology, Vrije Universiteit Amsterdam
- Allegonda H. M. Willemsen
- Department of Biological Psychology, Vrije Universiteit Amsterdam
- LAdrienne Cupples
- Department of Biostatistics, Boston University School of Public Health
- Joyce B. J. van Meurs
- Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam
- Mohsen Ghanbari
- Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam
- Penny Gordon-Larsen
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina
- Wei Huang
- Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai
- Young Jin Kim
- Division of Genome Science, Department of Precision Medicine, National Institute of Health
- Yasuharu Tabara
- Center for Genomic Medicine, Kyoto University Graduate School of Medicine
- Nicholas J. Wareham
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Claudia Langenberg
- MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine
- Eleftheria Zeggini
- Wellcome Trust Sanger Institute
- Johanna Kuusisto
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital
- Markku Laakso
- Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital
- Erik Ingelsson
- Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine
- Goncalo Abecasis
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- John C. Chambers
- Department of Epidemiology and Biostatistics, Imperial College London
- Jaspal S. Kooner
- Department of Cardiology, Ealing Hospital, London North West University Healthcare NHS Trust
- Paul S. de Vries
- Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston
- Alanna C. Morrison
- Human Genetics Center, Department of Epidemiology, School of Public Health, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston
- Scott Hazelhurst
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Michèle Ramsay
- Sydney Brenner Institute for Molecular Bioscience, Faculty of Health Sciences, University of the Witwatersrand
- Kari E. North
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina
- Martha Daviglus
- Institute for Minority Health Research, University of Illinois College of Medicine
- Peter Kraft
- Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health
- Nicholas G. Martin
- QIMR Berghofer Medical Research Institute
- John B. Whitfield
- QIMR Berghofer Medical Research Institute
- Shahid Abbas
- Center for Non-Communicable Diseases
- Danish Saleheen
- Center for Non-Communicable Diseases
- Robin G. Walters
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Michael V. Holmes
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford
- Corri Black
- Aberdeen Centre for Health Data Science,1:042 Polwarth Building School of Medicine, Medical Science and Nutrition University of Aberdeen
- Blair H. Smith
- Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee
- Aris Baras
- Regeneron Pharmaceuticals
- Anne E. Justice
- Department of Population Health Sciences, Geisinger Health
- Julie E. Buring
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Paul M. Ridker
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Daniel I. Chasman
- Division of Preventive Medicine, Brigham and Women’s Hospital
- Charles Kooperberg
- Fred Hutchinson Cancer Center, Division of Public Health Sciences
- Gen Tamiya
- Tohoku Medical Megabank Organization, Tohoku University
- Masayuki Yamamoto
- Tohoku Medical Megabank Organization, Tohoku University
- David A. van Heel
- Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Richard C. Trembath
- School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King’s College London
- Wei-Qi Wei
- Department of Biomedical Informatics, Vanderbilt University Medical Center
- Gail P. Jarvik
- Departments of Medicine (Medical Genetics) and Genome Sciences, University of Washington
- Bahram Namjou
- Center for Autoimmune Genomics and Etiology, Cincinnati Children’s Hospital Medical Center (CCHMC)
- M. Geoffrey Hayes
- Center for Genetic Medicine, Northwestern University, Feinberg School of Medicine
- Marylyn D. Ritchie
- Department of Genetics, Institute for Biomedical Informatics, University of Pennsylvania, Perelman School of Medicine
- Pekka Jousilahti
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare
- Veikko Salomaa
- Department of Public Health and Welfare, Finnish Institute for Health and Welfare
- Kristian Hveem
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Bjørn Olav Åsvold
- K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology
- Michiaki Kubo
- RIKEN Center for Integrative Medical Sciences
- Yoichiro Kamatani
- Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences
- Yukinori Okada
- Department of Statistical Genetics, Osaka University Graduate School of Medicine
- Yoshinori Murakami
- Division of Molecular Pathology, Institute of Medical Science, The University of Tokyo
- Bong-Jo Kim
- Division of Genome Science, Department of Precision Medicine, National Institute of Health
- Unnur Thorsteinsdottir
- deCODE Genetics/Amgen
- Kari Stefansson
- deCODE Genetics/Amgen
- Jifeng Zhang
- Department of Internal Medicine, Division of Cardiology, University of Michigan
- YEugene Chen
- Department of Internal Medicine, Division of Cardiology, University of Michigan
- Yuk-Lam Ho
- VA Boston Healthcare System
- Julie A. Lynch
- VA Informatics and Computing Infrastructure, VA Salt Lake City Health Care System
- Daniel J. Rader
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Philip S. Tsao
- VA Palo Alto Health Care Systems
- Kyong-Mi Chang
- Corporal Michael J. Crescenz VA Medical Center
- Kelly Cho
- VA Boston Healthcare System
- Christopher J. O’Donnell
- VA Boston Healthcare System
- John M. Gaziano
- VA Boston Healthcare System
- Peter W. F. Wilson
- Atlanta VA Health Care System
- Timothy M. Frayling
- Genetics of Complex Traits, University of Exeter Medical School, University of Exeter
- Joel N. Hirschhorn
- Boston Children’s Hospital
- Sekar Kathiresan
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Karen L. Mohlke
- Department of Genetics, University of North Carolina
- Yan V. Sun
- Department of Epidemiology, Emory University Rollins School of Public Health
- Andrew P. Morris
- Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, The University of Manchester
- Michael Boehnke
- Department of Biostatistics, Center for Statistical Genetics, University of Michigan
- Christopher D. Brown
- Department of Genetics, Perelman School of Medicine, University of Pennsylvania
- Pradeep Natarajan
- Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- Panos Deloukas
- William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London
- Cristen J. Willer
- Department of Internal Medicine, Division of Cardiology, University of Michigan
- Themistocles L. Assimes
- VA Palo Alto Health Care Systems
- Gina M. Peloso
- Department of Biostatistics, Boston University School of Public Health
- DOI
- https://doi.org/10.1186/s13059-022-02837-1
- Journal volume & issue
-
Vol. 23,
no. 1
pp. 1 – 42
Abstract
Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
Keywords
