Journal of Investigative Surgery (Nov 2021)

Effects of Trans-Cinnamaldehyde on Reperfused Ischemic Skeletal Muscle and the Relationship to Laminin

  • Esra Pekoglu,
  • Belgin Buyukakilli,
  • Cagatay Han Turkseven,
  • Ebru Balli,
  • Gulsen Bayrak,
  • Burak Cimen,
  • Senay Balci

DOI
https://doi.org/10.1080/08941939.2020.1802538
Journal volume & issue
Vol. 34, no. 12
pp. 1329 – 1338

Abstract

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Purpose Ischemia-reperfusion (I-R) injury is a serious problem caused by vascular trauma, tourniquet use and/or compartment syndrome. Studies have reported that skeletal muscle function is impaired due to the lower extremity I-R injury. There are insufficient studies on the treatment methods used for the recovery of dysfunction. This study is designed to investigate the effects of trans-cinnamaldehyde (TCA), a volatile oil of cinnamon structure, on the contractile dysfunction due to I-R injury of rat extensor-digitorum-longus (EDL) muscle. Materials and methods Sprague-Dawley rats were randomly divided into three groups. Except for the animals in the control group, all animals received saline (3-ml/kg) or TCA solution (30-mg/kg) which was administered orally three times with an 8-h interval before ischemia. After 24-hours, experimental groups were subjected to 3-h of lower extremity ischemia followed by 5-h reperfusion period. Then, the compound muscle action potential (CMAP) and mechanical activity of muscle were recorded using the standard electro-biophysical techniques. Results There was a decrease in the maximum contractile force in I-R group compared to the control group (p 0.05). Conclusion We concluded that TCA has a potential protective effect with antioxidant effects against I-R injury and may maintain laminin levels.

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