Influence of drug treatment with antidepressants and antipsychotics on plasma urea levels

Abstract

Roberto Lozano OrtizPharmacy Department, Hospital Real Nuestra Señora de Gracia, Zaragoza, SpainHaving read with great interest the article by Goto et al1 and in order to clarify further some of the results presented in this article, especially with regard to the action of atypical antipsychotic drugs on glutamate and the glutamine to creatine ratio, it would seem appropriate to reiterate the comments made by Lozano et al in a presentation at the 55th National Congress of the Spanish Association of Hospital Pharmacists in 2010, where we proposed the likely oxide, glutamine, and glutamate levels in the brain, as a result of the reaction of nitric oxide with glutamine to yield glutamate and nitrogen gas. A summary of this research is provided as follows.View original paper by Goto and colleagues.