West Nile Virus infection in a renal transplant recipient resulting in polioencephalomylelitis, quadriplegia, and global brain atrophy
Kamran Kadkhoda,
John M. Embil,
Lundy R. McKibbin,
James McEachern,
Michael A. Drebot
Affiliations
Kamran Kadkhoda
Immunopathology Laboratory, Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA; Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Corresponding author at: Robert J. Tomsich Pathology & Laboratory Medicine Institute, Cleveland Clinic, 10300 Carnegie Ave. LL3-150, Cleveland, OH, 44106, USA.
John M. Embil
Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; Department of Internal Medicine, Section of Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
Lundy R. McKibbin
Department of Internal Medicine, Section of General Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
James McEachern
Department of Diagnostic Imaging, Health Sciences Centre, Winnipeg, Manitoba, Canada
Michael A. Drebot
Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada; National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
An immunosuppressed man developed rapidly progressive neurologic symptoms resulting in quadriplegia. On magnetic resonance imaging multiple areas of abnormal enhancement were observed in the brain, and spinal cord. Serologic evidence of West Nile Virus (WNV) was discovered in the cerebrospinal fluid. This report highlights the catastrophic complications of WNV in an immunocompromised host. Keywords: West Nile Virus, Immunocompromised, Quadriplegia, Encephalomyelitis, Renal transplant
