The Potential Roles of Exosomes in Chronic Obstructive Pulmonary Disease

Nan Wang; Qin Wang; Tiantian Du; Abakundana Nsenga Ariston Gabriel; Xue Wang; Li Sun; Xiaomeng Li; Kanghong Xu; Xinquan Jiang; Yi Zhang

doi:10.3389/fmed.2020.618506

Frontiers in Medicine (Jan 2021)

The Potential Roles of Exosomes in Chronic Obstructive Pulmonary Disease

Nan Wang,
Qin Wang,
Tiantian Du,
Abakundana Nsenga Ariston Gabriel,
Xue Wang,
Li Sun,
Xiaomeng Li,
Kanghong Xu,
Xinquan Jiang,
Yi Zhang

Affiliations

Nan Wang: School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China
Qin Wang: Department of Anesthesiology, Qilu Hospital, Shandong University, Jinan, China
Tiantian Du: Department of Clinical Laboratory, Cheeloo College of Medicine, The Second Hospital, Shandong University, Jinan, China
Abakundana Nsenga Ariston Gabriel: Department of Clinical Laboratory, Cheeloo College of Medicine, The Second Hospital, Shandong University, Jinan, China
Xue Wang: Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, China
Li Sun: School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China
Xiaomeng Li: School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China
Kanghong Xu: School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China
Xinquan Jiang: School of Public Health, Shandong First Medical University and Shandong Academy of Medical Sciences, Taian, China
Yi Zhang: Respiratory and Critical Care Medicine Department, Qilu Hospital, Shandong University, Jinan, China

DOI: https://doi.org/10.3389/fmed.2020.618506
Journal volume & issue: Vol. 7

Abstract

Read online

Currently, chronic obstructive pulmonary disease (COPD) is one of the most common chronic lung diseases. Chronic obstructive pulmonary disease is characterized by progressive loss of lung function due to chronic inflammatory responses in the lungs caused by repeated exposure to harmful environmental stimuli. Chronic obstructive pulmonary disease is a persistent disease, with an estimated 384 million people worldwide living with COPD. It is listed as the third leading cause of death. Exosomes contain various components, such as lipids, microRNAs (miRNAs), long non-coding RNAs(lncRNAs), and proteins. They are essential mediators of intercellular communication and can regulate the biological properties of target cells. With the deepening of exosome research, it is found that exosomes are strictly related to the occurrence and development of COPD. Therefore, this review aims to highlight the unique role of immune-cell-derived exosomes in disease through complex interactions and their potentials as potential biomarkers new types of COPD.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

About the journal

Abstract

Keywords