Sympathetic Vagal Balance and Cognitive Performance in Young Adults during the NIH Cognitive Test

Abstract

Compromised cognitive function is associated with increased mortality and increased healthcare costs. Autonomic nervous system arousal, as measured by an electrocardiogram (ECG), has received recent attention because of its association with the blood perfusion of brain regions involved with cognitive function. The purposes of this study were to determine whether the ECG HR variation, as measured by the standard deviation of the heart rate N-to-N intervals (SDNN), and sympathetic vagal tone, as estimated by the low-frequency/high-frequency ratio (LF/HF), are increased with cognitive performance during the NIH Cognitive Test (Picture Sequence, Dimensional Change Card Sort, Flanker, and List Sorting). A total of 62 young people without cognitive impairment participated in this study. We discovered that the ECG LF/HF ratio was increased in the top 50% of participants who could: (1) inhibit information and stay attentive to a desired task during the Flanker Test; (U = 329, p = 0.03; R2 = 0.76); and (2) promote cognitive function flexibility during the DCCS Test; (U = 55, p = 0.007; R2 = 0.98). Taken together, these findings support that the arousal level influences performance during a cognitive test.

Keywords

• autonomic nervous system
• cognitive function
• sympathetic vagal balance
• heart rate variability