Evaluation of the Triglyceride Glucose Index as a Marker of Insulin Resistance in Adults with Isolated Impaired Glucose Tolerance

Abstract

Purpose: By analyzing long-term laboratory data, we aim to evaluate the relationship between the TyG and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) in the adult population with isolated impaired fasting glucose (IFG), and also to determine the cut off value of The triglyceride (TG) to glucose index (TyG) to estimate the IR in our population. Materials and Methods: In this study, data were evaluated retrospectively from medical records. Fasting glucose, lipid panel [Total cholesterol, TG, High-density lipoprotein (HDL), Low-density lipoprotein (LDL)] and insulin levels were analyzed with commercially reagents. (Roche Cobas C701, Roche Diagnostic, Germany). High-Performance Liquid Chromatography (HPLC) method was used for hemoglobin A1c (HbA1c) (Lifotronic H9, Lifotrophic Technology, China). TyG, HOMA-IR, and TG/HDLcholesterol were calculated. IR was defined as HOMA-IR ≥2.5. Results: A total of 440 subject, (controls: 230 and IFG:210), were included in our study. The average age of the subjects was 42.5±12.0 years and 44.7±10.7 years for IFG and control, respectively. Glucose, total cholesterol, TG, LDL-cholesterol, insulin, HbA1c, TG/HDL-cholesterol, HOMA-IR, and TyG were significantly higher in the IFG group (p<0.001). There was a weak but significant correlation between HOMA-IR and the TyG (r=0.210, p=0.009). In the ROC analysis, the AUC for HOMA-IR and the TyG, respectively was 0.867 (95% CI, 0.833-0.900, p<0.001) and 0.708 (95% CI, 0.659-0.758, p<0.001). Conclusions: In our study, the TyG is proposed as a relatively accurate, simple, easily accessible, and low-cost marker for IR evaluation with IFG patients. However, population-based studies with higher patient participation are needed for future studies.

Keywords

• homa-ir
• insulin resistance
• tg/hdl-c
• tyg index
• impaired fasting glucose
• impaired glucose tolerance