Nature Communications (Mar 2018)

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis

  • Sébastien Thériault,
  • Nathalie Gaudreault,
  • Maxime Lamontagne,
  • Mickael Rosa,
  • Marie-Chloé Boulanger,
  • David Messika-Zeitoun,
  • Marie-Annick Clavel,
  • Romain Capoulade,
  • François Dagenais,
  • Philippe Pibarot,
  • Patrick Mathieu,
  • Yohan Bossé

DOI
https://doi.org/10.1038/s41467-018-03260-6
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 8

Abstract

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Progressive remodeling and calcification of the aortic valve leads to calcific aortic valve stenosis (CAVS) and, ultimately, heart failure. In a combined GWAS and TWAS approach, Thériault et al. identify PALMD as a candidate causal gene for CAVS, which is further supported by Mendelian randomization.