Nature Communications (Nov 2020)
A stem cell reporter based platform to identify and target drug resistant stem cells in myeloid leukemia
- Kyle Spinler,
- Jeevisha Bajaj,
- Takahiro Ito,
- Bryan Zimdahl,
- Michael Hamilton,
- Armin Ahmadi,
- Claire S. Koechlein,
- Nikki Lytle,
- Hyog Young Kwon,
- Ferdous Anower-E-Khuda,
- Hao Sun,
- Allen Blevins,
- Joi Weeks,
- Marcie Kritzik,
- Jan Karlseder,
- Mark H. Ginsberg,
- Pyong Woo Park,
- Jeffrey D. Esko,
- Tannishtha Reya
Affiliations
- Kyle Spinler
- Department of Pharmacology, University of California San Diego School of Medicine
- Jeevisha Bajaj
- Department of Pharmacology, University of California San Diego School of Medicine
- Takahiro Ito
- Department of Pharmacology, University of California San Diego School of Medicine
- Bryan Zimdahl
- Department of Pharmacology, University of California San Diego School of Medicine
- Michael Hamilton
- Department of Pharmacology, University of California San Diego School of Medicine
- Armin Ahmadi
- Department of Pharmacology, University of California San Diego School of Medicine
- Claire S. Koechlein
- Department of Pharmacology, University of California San Diego School of Medicine
- Nikki Lytle
- Department of Pharmacology, University of California San Diego School of Medicine
- Hyog Young Kwon
- Department of Pharmacology, University of California San Diego School of Medicine
- Ferdous Anower-E-Khuda
- Department of Cellular and Molecular Medicine, University of California San Diego School of Medicine
- Hao Sun
- Department of Medicine, University of California San Diego
- Allen Blevins
- Department of Pharmacology, University of California San Diego School of Medicine
- Joi Weeks
- Department of Pharmacology, University of California San Diego School of Medicine
- Marcie Kritzik
- Department of Pharmacology, University of California San Diego School of Medicine
- Jan Karlseder
- Salk Institute
- Mark H. Ginsberg
- Department of Medicine, University of California San Diego
- Pyong Woo Park
- Department of Medicine, Boston Children’s Hospital, Harvard Medical School
- Jeffrey D. Esko
- Department of Cellular and Molecular Medicine, University of California San Diego School of Medicine
- Tannishtha Reya
- Department of Pharmacology, University of California San Diego School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-19782-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Identifying leukaemia stem cells (LSC) and defining how they drive tumourigenesis might aid in the treatment of disease. Here, the authors show that a reporter Musashi 2 can serve as a platform to effectively identify leukemic stem cells and it is used to define Syndecan-1 as a dependency for these aggressive, therapy resistant cells.
