Histopathological Changes Induced by Monosodium Glutamate and Sodium Nitrite in the Development of Eye in Albino Mice Mus musculus

Abstract

The present study aimed to discover the histopathological of the Monosodium glutamate (MSG), and Sodium nitrite (NaNO2), on the embryonic development of the eyes of albino mice Mus musculus. On the fourteenth and eighteenth day of pregnancy, the stage of organogenesis in these animals. A concentration of 9 g/kg of MSG, a concentration of 110 mg/kg of NaNO2, and the interaction between them used. The results of the study showed the presence of pathological changes to the eyes of the fetuses. The eye on the 14th day of pregnancy, when 9 g/kg of MSG used, there were retinal duplication, increased vascularization in the retina, condensation of some nuclei of the inner nuclear layer and ganglion cells, and necrosis in the vicinity of the lens. When treating with NaNO2 110 mg/kg, there was an irregularity in the lens, corneal distortion, hyperplasia of the retinal nerve tissue. When the two materials overlapped, the corneal tissue necrosis, the lens fiber, and the inner plexiform layer were observed. On the 18th day of pregnancy, when treated with MSG 9g/kg, the most significant overall and striking damage was retinal duplication and optic nerve necrosis. When treated with NaNO2 110 mg/kg, the corneal stroma and dissociation were seen in the photoreceptor cells. In the case of their overlapping, extensive necrosis and reduction appeared in all layers of the retina. The study concluded that consuming MSG and NaNO2 more than the permissible limit during pregnancy leads to tissue lesions harmful to the eye.

Keywords

• food additives
• fetal development of the eye
• msg
• nano2