精准医学杂志 (Feb 2023)
VALUE OF GD-EOB-DTPA-ENHANCED MRI T1 MAPPING IN EVALUATING THE PATHOLOGICAL GRADE OF HEPATOCELLULAR CARCINOMA
Abstract
Objective To investigate the value of T1 value before and after Gd-EOB-DTPA-enhanced MRI in evaluating the pathological grade of hepatocellular carcinoma (HCC). Methods A retrospective analysis was performed for the plain scan and Gd-EOB-DTPA-enhanced MRI images of 75 HCC patients (75 lesions in total) who were admitted to The Affiliated Hospital of Qingdao University from March 2019 to June 2020. According to Edmondson-Steiner grading, lesions were divided into low-grade group (grade Ⅰ-Ⅱ) and high-grade group (grade Ⅲ-Ⅳ). The T1 mapping technique was used to measure pre-enhanced T1 value (T1pre) and hepatobiliary-specific T1 value (T1-HBP), and the reduction in T1 value (△T1) and the reduction rate of T1 value (△T1%) were calculated. T1pre, T1-HBP, △T1, and △T1% were compared between the lesions with different pathological grades, and the correlation between each quantitative index and pathological grade was analyzed. The receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) were used to analyze the efficiency of each statistically significant index. Results There were significant differences in T1pre, T1-HBP, and △T1% between the low-grade group and the high-grade group (t=-3.725-2.551,P<0.05), while there was no significant difference in △T1 between the two groups (P>0.05). Correlation analysis showed that T1pre and T1-HBP were positively correlated with the pathological grade of HCC (r=0.293,0.472,P<0.05), and △T1% was negatively correlated with the pathological grade of HCC (r=-0.254,P<0.05); there was no significant correlation between △T1 and the pathological grade of HCC. T1pre, T1-HBP, and △T1% had an AUC of 0.676 (95%CI=0.542-0.810,P<0.05), 0.784 (95%CI=0.671-0.897,P<0.05), and 0.654 (95%CI=0.531-0.775,P<0.05), respectively, in differentiating between low-grade HCC and high-grade HCC, with a sensitivity of 72.9%, 83.3%, and 39.6%, respectively, and a specificity of 63.0%, 74.1%, and 92.6%, respectively, at the optimal cut-off values of 1 253.5 ms, 875.5 ms, and 40.5%, respectively. Conclusion T1pre, T1-HBP, and △T1% of Gd-EOB-DTPA-enhanced MRI have a certain value in predicting the pathological grade of HCC.
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