Nature Communications (Jul 2019)

Transient drug-tolerance and permanent drug-resistance rely on the trehalose-catalytic shift in Mycobacterium tuberculosis

  • Jae Jin Lee,
  • Sun-Kyung Lee,
  • Naomi Song,
  • Temitope O. Nathan,
  • Benjamin M. Swarts,
  • Seok-Yong Eum,
  • Sabine Ehrt,
  • Sang-Nae Cho,
  • Hyungjin Eoh

DOI
https://doi.org/10.1038/s41467-019-10975-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Trehalose metabolism has been linked to Mycobacterium tuberculosis (Mtb) virulence and biofilm formation. Here, using a model of drug-tolerant persisters and metabolomics, the authors dissect the role of trehalose metabolism in Mtb persister formation, linking trehalose-catalytic shift to antibiotic resistance.