Communications Biology (Apr 2022)
Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia
- Zhiqiang Wang,
- Chunxiao Zhang,
- Charles David Warden,
- Zheng Liu,
- Yate-Ching Yuan,
- Chao Guo,
- Charles Wang,
- Jinhui Wang,
- Xiwei Wu,
- Richard Ermel,
- Steven L. Vonderfecht,
- Xiuli Wang,
- Christine Brown,
- Stephen Forman,
- Yaling Yang,
- M. James You,
- WenYong Chen
Affiliations
- Zhiqiang Wang
- Department of Cancer Biology, Beckman Research Institute, City of Hope
- Chunxiao Zhang
- Department of Cancer Biology, Beckman Research Institute, City of Hope
- Charles David Warden
- Integrative Genomics Core, Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope
- Zheng Liu
- Department of Molecular Medicine, Beckman Research Institute, City of Hope
- Yate-Ching Yuan
- Department of Molecular Medicine, Beckman Research Institute, City of Hope
- Chao Guo
- Department of Molecular Medicine, Beckman Research Institute, City of Hope
- Charles Wang
- Department of Molecular Medicine, Beckman Research Institute, City of Hope
- Jinhui Wang
- Integrative Genomics Core, Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope
- Xiwei Wu
- Integrative Genomics Core, Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope
- Richard Ermel
- Center for Comparative Medicine, Beckman Research Institute, City of Hope
- Steven L. Vonderfecht
- Consultant in Veterinary Pathology
- Xiuli Wang
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center
- Christine Brown
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center
- Stephen Forman
- Department of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center
- Yaling Yang
- Department of Hematopathology, The University of Texas MD Anderson Cancer Center
- M. James You
- Department of Hematopathology, The University of Texas MD Anderson Cancer Center
- WenYong Chen
- Department of Cancer Biology, Beckman Research Institute, City of Hope
- DOI
- https://doi.org/10.1038/s42003-022-03340-w
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 15
Abstract
Studies employing serial bone marrow transplantation in mice show that Sirt1 knockout improves quiescence maintenance and function of aging hematopoietic stem cells. Sirt1 loss also prevents the development of age-dependent B/myeloid mixed phenotype acute leukemia.
