The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in Children

Yu-Wen Liu; Jia-Feng Wu; Huey-Ling Chen; Hong-Yuan Hsu; Mei-Hwei Chang; Wei-Chung Hsu; Ping-Huei Tseng; Hsiu-Po Wang; Yen-Hsuan Ni

doi:10.1016/j.pedneo.2015.09.008

Pediatrics and Neonatology (Oct 2016)

The Correlation between Endoscopic Reflux Esophagitis and Combined Multichannel Intraluminal Impedance-pH Monitoring in Children

Yu-Wen Liu,
Jia-Feng Wu,
Huey-Ling Chen,
Hong-Yuan Hsu,
Mei-Hwei Chang,
Wei-Chung Hsu,
Ping-Huei Tseng,
Hsiu-Po Wang,
Yen-Hsuan Ni

Affiliations

Yu-Wen Liu: Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
Jia-Feng Wu: Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
Huey-Ling Chen: Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
Hong-Yuan Hsu: Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
Mei-Hwei Chang: Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
Wei-Chung Hsu: Department of Otolaryngology, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
Ping-Huei Tseng: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
Hsiu-Po Wang: Department of Internal Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan
Yen-Hsuan Ni: Department of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan

DOI: https://doi.org/10.1016/j.pedneo.2015.09.008
Journal volume & issue: Vol. 57, no. 5
pp. 385 – 389

Abstract

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Gastroesophageal reflux (GER) is the retrograde flow of gastric contents into the esophagus and may induce a variety of complications. Endoscopically visible breaks in the distal esophageal mucosa are the most reliable evidence of reflux esophagitis. Combined multichannel intraluminal impedance and pH-metry (MII-pH) is a technique that enables monitoring of GER independent of its acidity. The aim of this study is to investigate the GER patterns in children with the aid of MII-pH monitoring and determine the correlation between endoscopically proven reflux esophagitis and reflux types by MII-pH monitoring. Methods: One hundred and twenty children were enrolled from January 2010 to October 2011 for MII-pH monitoring. We studied the GER patterns by means of pH (acid and nonacid reflux) and composition (liquid, mixed, and gas reflux) by the esophageal MII-pH signals. Meanwhile, 34 (28.3%) patients received esophagogastroduodenoscopy examination at the same time. The severity of reflux esophagitis was graded with Los Angeles classification. Results: MII-pH monitoring significantly increased the detection of numbers of reflux compared with traditional 24-hour pH monitoring (p < 0.001). The significant cutoff value of MII-pH parameters including DeMeester score ≥ 21, duration of longest acid reflux ≥ 17 minutes, and occurrence of acid reflux for more than 5 minutes showed good correlation in the prediction of the presence of endoscopic reflux esophagitis. The odds ratios of the above mentioned parameters were 12.6, 8.94, and 7.5, respectively (p = 0.02, p = 0.01, and p = 0.01). Furthermore, ≥ 3 episodes per day of acid reflux for more than 5 minutes can predict the occurrence of severe reflux esophagitis (odds ratio 12.78, p = 0.009). Conclusion: MII-pH monitoring not only raised the diagnostic yield in identifying GER, but it also showed significant correlation with the presence of endoscopically proven reflux esophagitis in children.

Published in Pediatrics and Neonatology

ISSN: 1875-9572 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Pediatrics
Website: https://www.journals.elsevier.com/pediatrics-and-neonatology/

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