Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson’s Disease
Guowang Cheng,
Xueliang Liu,
Yujing Liu,
Yao Liu,
Rui Ma,
Jingshan Luo,
Xinyi Zhou,
Zhenfeng Wu,
Zhuang Liu,
Tongkai Chen,
Yu Yang
Affiliations
Guowang Cheng
Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Xueliang Liu
Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China
Yujing Liu
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
Yao Liu
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
Rui Ma
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
Jingshan Luo
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
Xinyi Zhou
Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China; School of Cellular and Molecular Medicine, University of Bristol, Bristol BS8 1TH, UK
Zhenfeng Wu
Key Laboratory of Modern Preparation of Traditional Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China
Zhuang Liu
Institute of Functional Nano & Soft Materials Laboratory (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China
Tongkai Chen
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou 510405, China
Yu Yang
Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200240, China
Parkinson’s disease (PD) is the second most common neurodegenerative disease globally, and there is currently no effective treatment for this condition. Excessive accumulation of reactive oxygen species (ROS) and neuroinflammation are major contributors to PD pathogenesis. Herein, ultrasmall nanoscale coordination polymers (NCPs) coordinated by ferric ions and natural product curcumin (Cur) were exploited, showing efficient neuroprotection by scavenging excessive radicals and suppressing neuroinflammation. In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse PD model, such ultrasmall Fe-Cur NCPs with prolonged blood circulation and BBB traversing capability could effectively alleviate oxidative stress, mitochondrial dysfunction, and inflammatory condition in the midbrain and striatum to reduce PD symptoms. Thus, this study puts forth a unique type of therapeutics-based NCPs that could be used for safe and efficient treatment of PD with potential in clinical translation.
