International Journal of Nanomedicine (Dec 2021)

Preparation of Zirconium Hydrogen Phosphate Coatings on Sandblasted/Acid-Etched Titanium for Enhancing Its Osteoinductivity and Friction/Corrosion Resistance

  • Fang K,
  • Shen Y,
  • Ru Yie KH,
  • Zhou Z,
  • Cai L,
  • Wu S,
  • Al-Bishari AM,
  • Al-Baadani MA,
  • Shen X,
  • Ma P,
  • Liu J

Journal volume & issue
Vol. Volume 16
pp. 8265 – 8277


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Kai Fang,* Yiding Shen,* Kendrick Hii Ru Yie, Zixin Zhou, Lei Cai, Shuyi Wu, Abdullrahman M Al-Bishari, Mohammed A Al-Baadani, Xinkun Shen, Pingping Ma, Jinsong Liu School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xinkun Shen; Pingping MaSchool and Hospital of Stomatology, Wenzhou Medical University, 268#Xueyuan West Road, Lucheng District, Wenzhou City, 325000, People’s Republic of ChinaTel +86-577-88066010; +86-577-88066085Email [email protected]; [email protected]: Sandblasted/acid-etched titanium (SLA-Ti) implants are widely used for dental implant restoration in edentulous patients. However, the poor osteoinductivity and the large amount of Ti particles/ions released due to friction or corrosion will affect its long-term success rate.Purpose: Various zirconium hydrogen phosphate (ZrP) coatings were prepared on SLA-Ti surface to enhance its friction/corrosion resistance and osteoinduction.Methods: The mixture of ZrCl4 and H3PO4 was first coated on SLA-Ti and then calcined at 450°C for 5 min to form ZrP coatings. In addition to a series of physiochemical characterization such as morphology, roughness, wettability, and chemical composition, their capability of anti-friction and anti-corrosion were further evaluated by friction-wear test and by potential scanning. The viability and osteogenic differentiation of MC3T3-E1 cells on different substrates were investigated via MTT, mineralization and PCR assays.Results: The characterization results showed that there were no significant changes in the morphology, roughness and wettability of ZrP-modified samples (SLA-ZrP0.5 and SLA-ZrP0.7) compared with SLA group. The results of electrochemical corrosion displayed that both SLA-ZrP0.5 and SLA-ZrP0.7 (especially the latter) had better corrosion resistance than SLA in normal saline and serum-containing medium. SLA-ZrP0.7 also exhibited the best friction resistance and great potential to enhance the spreading, proliferation and osteogenic differentiation of MC3T3-E1 cells.Conclusion: We determined that SLA-ZrP0.7 had excellent comprehensive properties including anti-corrosion, anti-friction and osteoinduction, which made it have a promising clinical application in dental implant restoration.Keywords: titanium, zirconium hydrogen phosphate, anti-corrosion, anti-friction, osteoinduction