Translational Psychiatry (Jun 2022)
Reduced nucleus accumbens functional connectivity in reward network and default mode network in patients with recurrent major depressive disorder
- Yu-Dan Ding,
- Xiao Chen,
- Zuo-Bing Chen,
- Le Li,
- Xue-Ying Li,
- Francisco Xavier Castellanos,
- Tong-Jian Bai,
- Qi-Jing Bo,
- Jun Cao,
- Zhi-Kai Chang,
- Guan-Mao Chen,
- Ning-Xuan Chen,
- Wei Chen,
- Chang Cheng,
- Yu-Qi Cheng,
- Xi-Long Cui,
- Jia Duan,
- Yi-Ru Fang,
- Qi-Yong Gong,
- Zheng-Hua Hou,
- Lan Hu,
- Li Kuang,
- Feng Li,
- Hui-Xian Li,
- Kai-Ming Li,
- Tao Li,
- Yan-Song Liu,
- Zhe-Ning Liu,
- Yi-Cheng Long,
- Bin Lu,
- Qing-Hua Luo,
- Hua-Qing Meng,
- Dai-Hui Peng,
- Hai-Tang Qiu,
- Jiang Qiu,
- Yue-Di Shen,
- Yu-Shu Shi,
- Tian-Mei Si,
- Yan-Qing Tang,
- Chuan-Yue Wang,
- Fei Wang,
- Kai Wang,
- Li Wang,
- Xiang Wang,
- Ying Wang,
- Yu-Wei Wang,
- Xiao-Ping Wu,
- Xin-Ran Wu,
- Chun-Ming Xie,
- Guang-Rong Xie,
- Hai-Yan Xie,
- Peng Xie,
- Xiu-Feng Xu,
- Hong Yang,
- Jian Yang,
- Jia-Shu Yao,
- Shu-Qiao Yao,
- Ying-Ying Yin,
- Yong-Gui Yuan,
- Yu-Feng Zang,
- Ai-Xia Zhang,
- Hong Zhang,
- Ke-Rang Zhang,
- Lei Zhang,
- Zhi-Jun Zhang,
- Jing-Ping Zhao,
- Ru-Bai Zhou,
- Yi-Ting Zhou,
- Jun-Juan Zhu,
- Zhi-Chen Zhu,
- Chao-Jie Zou,
- Xi-Nian Zuo,
- Chao-Gan Yan,
- Wen-Bin Guo
Affiliations
- Yu-Dan Ding
- Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University
- Xiao Chen
- CAS Key Laboratory of Behavioral Science, Institute of Psychology
- Zuo-Bing Chen
- Department of Rehabilitation Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University
- Le Li
- Center for Cognitive Science of Language, Beijing Language and Culture University
- Xue-Ying Li
- CAS Key Laboratory of Behavioral Science, Institute of Psychology
- Francisco Xavier Castellanos
- Department of Child and Adolescent Psychiatry, NYU Grossman School of Medicine
- Tong-Jian Bai
- Anhui Medical University
- Qi-Jing Bo
- Beijing Anding Hospital, Capital Medical University
- Jun Cao
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University
- Zhi-Kai Chang
- CAS Key Laboratory of Behavioral Science, Institute of Psychology
- Guan-Mao Chen
- The First Affiliated Hospital of Jinan University
- Ning-Xuan Chen
- CAS Key Laboratory of Behavioral Science, Institute of Psychology
- Wei Chen
- Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Chang Cheng
- Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University
- Yu-Qi Cheng
- Department of Psychiatry, First Affiliated Hospital of Kunming Medical University
- Xi-Long Cui
- Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University
- Jia Duan
- Department of Psychiatry, First Affiliated Hospital, China Medical University
- Yi-Ru Fang
- Department of Psychiatry, Shanghai Jiao Tong University School of Medicine
- Qi-Yong Gong
- Huanxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University
- Zheng-Hua Hou
- Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University
- Lan Hu
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University
- Li Kuang
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University
- Feng Li
- Beijing Anding Hospital, Capital Medical University
- Hui-Xian Li
- CAS Key Laboratory of Behavioral Science, Institute of Psychology
- Kai-Ming Li
- Huanxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University
- Tao Li
- Mental Health Center, West China Hospital, Sichuan University
- Yan-Song Liu
- Department of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University
- Zhe-Ning Liu
- Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University
- Yi-Cheng Long
- Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University
- Bin Lu
- CAS Key Laboratory of Behavioral Science, Institute of Psychology
- Qing-Hua Luo
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University
- Hua-Qing Meng
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University
- Dai-Hui Peng
- Department of Psychiatry, Shanghai Jiao Tong University School of Medicine
- Hai-Tang Qiu
- Department of Psychiatry, The First Affiliated Hospital of Chongqing Medical University
- Jiang Qiu
- Faculty of Psychology, Southwest University
- Yue-Di Shen
- Department of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School
- Yu-Shu Shi
- Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University
- Tian-Mei Si
- National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University)
- Yan-Qing Tang
- Department of Psychiatry, First Affiliated Hospital, China Medical University
- Chuan-Yue Wang
- Beijing Anding Hospital, Capital Medical University
- Fei Wang
- Department of Psychiatry, First Affiliated Hospital, China Medical University
- Kai Wang
- Anhui Medical University
- Li Wang
- National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University)
- Xiang Wang
- Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University
- Ying Wang
- The First Affiliated Hospital of Jinan University
- Yu-Wei Wang
- CAS Key Laboratory of Behavioral Science, Institute of Psychology
- Xiao-Ping Wu
- Xi’an Central Hospital
- Xin-Ran Wu
- Faculty of Psychology, Southwest University
- Chun-Ming Xie
- Department of Neurology, Affiliated ZhongDa Hospital of Southeast University
- Guang-Rong Xie
- Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University
- Hai-Yan Xie
- Department of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University
- Peng Xie
- Institute of Neuroscience, Chongqing Medical University
- Xiu-Feng Xu
- Department of Psychiatry, First Affiliated Hospital of Kunming Medical University
- Hong Yang
- Department of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University
- Jian Yang
- Chongqing Key Laboratory of Neurobiology
- Jia-Shu Yao
- Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
- Shu-Qiao Yao
- Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University
- Ying-Ying Yin
- Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University
- Yong-Gui Yuan
- Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University
- Yu-Feng Zang
- Center for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University
- Ai-Xia Zhang
- The First Affiliated Hospital of Xi’an Jiaotong University
- Hong Zhang
- Xi’an Central Hospital
- Ke-Rang Zhang
- First Hospital of Shanxi Medical University
- Lei Zhang
- Laboratory of Psychological Health and Imaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine
- Zhi-Jun Zhang
- Department of Neurology, Affiliated ZhongDa Hospital of Southeast University
- Jing-Ping Zhao
- Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University
- Ru-Bai Zhou
- Department of Psychiatry, Shanghai Jiao Tong University School of Medicine
- Yi-Ting Zhou
- Mental Health Center, West China Hospital, Sichuan University
- Jun-Juan Zhu
- Department of Psychiatry, Shanghai Jiao Tong University School of Medicine
- Zhi-Chen Zhu
- CAS Key Laboratory of Behavioral Science, Institute of Psychology
- Chao-Jie Zou
- Department of Psychiatry, First Affiliated Hospital of Kunming Medical University
- Xi-Nian Zuo
- State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University
- Chao-Gan Yan
- CAS Key Laboratory of Behavioral Science, Institute of Psychology
- Wen-Bin Guo
- Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South University
- DOI
- https://doi.org/10.1038/s41398-022-01995-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 9
Abstract
Abstract The nucleus accumbens (NAc) is considered a hub of reward processing and a growing body of evidence has suggested its crucial role in the pathophysiology of major depressive disorder (MDD). However, inconsistent results have been reported by studies on reward network-focused resting-state functional MRI (rs-fMRI). In this study, we examined functional alterations of the NAc-based reward circuits in patients with MDD via meta- and mega-analysis. First, we performed a coordinated-based meta-analysis with a new SDM-PSI method for all up-to-date rs-fMRI studies that focused on the reward circuits of patients with MDD. Then, we tested the meta-analysis results in the REST-meta-MDD database which provided anonymous rs-fMRI data from 186 recurrent MDDs and 465 healthy controls. Decreased functional connectivity (FC) within the reward system in patients with recurrent MDD was the most robust finding in this study. We also found disrupted NAc FCs in the DMN in patients with recurrent MDD compared with healthy controls. Specifically, the combination of disrupted NAc FCs within the reward network could discriminate patients with recurrent MDD from healthy controls with an optimal accuracy of 74.7%. This study confirmed the critical role of decreased FC in the reward network in the neuropathology of MDD. Disrupted inter-network connectivity between the reward network and DMN may also have contributed to the neural mechanisms of MDD. These abnormalities have potential to serve as brain-based biomarkers for individual diagnosis to differentiate patients with recurrent MDD from healthy controls.