Serum ferritin is a risk factor for pulmonary dysfunction in young patients with transfusion-dependent thalassemia
Xiao Liang,
Gaohui Yang,
Lingling Shi,
Lianjin Liu,
Zhenbin Wei,
Yumei Huang,
Jing Bai,
Yi Liang,
Lingyuan Pan,
Zhaoping Gan,
Yu Lin,
Yibin Yao,
Ying Tang,
Huicheng Huang,
Xuemei Zhou,
Yongrong Lai,
Rongrong Liu
Affiliations
Xiao Liang
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Gaohui Yang
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Lingling Shi
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Lianjin Liu
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Zhenbin Wei
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Yumei Huang
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Jing Bai
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Yi Liang
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Lingyuan Pan
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Zhaoping Gan
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Yu Lin
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Yibin Yao
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Ying Tang
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Huicheng Huang
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Xuemei Zhou
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China
Yongrong Lai
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China; NHC Key Laboratory of Thalassemia Medicine, China; Guangxi Key Laboratory of Thalassemia Research, China; Corresponding authors. Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Rongrong Liu
Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China; NHC Key Laboratory of Thalassemia Medicine, China; Guangxi Key Laboratory of Thalassemia Research, China; Corresponding authors. Department of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Research into the pulmonary function of patients with transfusion-dependent thalassemia (TDT) is limited, with existing studies presenting conflicting results. We carried out a retrospective study involving 140 patients with TDT. The mean patient age was 8.7 ± 3.2 years, with a median serum ferritin (SF) level of 3791.4 ng/ml (IQR: 2424.1–5733.3 ng/ml). Pulmonary function abnormalities were detected in 46.43 % (65 out of 140) of patients, primarily manifesting as diffusion dysfunction (26.43 %), followed by ventilatory dysfunction (5.0 %), and mixed pulmonary dysfunction (15.0 %). A serum ferritin level above 2500 ng/ml significantly correlated with the occurrence of these abnormalities(OR = 3.187, 95%CI:1.312–7.741, P = 0.010), while higher hemoglobin concentrations demonstrated a protective effect (OR = 0.966, 95%CI: 0.943–0.989, P = 0.004). Our study highlights diffusion dysfunction as the most prevalent type of pulmonary function abnormalities in TDT patients. Furthermore, it establishes a correlation between elevated serum ferritin levels and pulmonary dysfunction.
