Quantitative Imaging of the Iron-Oxide Nanoparticle- Concentration for Magnetic Drug Targeting Employing Inverse Magnetomotive Ultrasound

Abstract

Magnetomotive Ultrasound is an imaging technique that is capable to detect tissue, which is perfused by magnetic nanoparticles. However, this modality is restricted to qualitative imaging only. Therefore, we present an extended Magnetomotive Ultrasound algorithm, which allows the quantitative determination of the spatial distribution of magnetic nanoparticle density in tissue. The algorithm is based on an iterative adjustment of simulated data to measurements. Experiments with tissue-mimicking phantoms reveal that the presented method leads to the spatial particle concentration in the correct order of magnitude.

Keywords

• magnetic drug targeting
• magnetomotive ultrasound
• iron-oxide nanoparticles
• ultrasonic imaging
• iterative method