Suppression of flavivirus transmission from animal hosts to mosquitoes with a mosquito-delivered vaccine

Dan Wen; Limin S. Ding; Yanan Zhang; Xiaoye Li; Xing Zhang; Fei Yuan; Tongbiao Zhao; Aihua Zheng

doi:10.1038/s41467-022-35407-x

Nature Communications (Dec 2022)

Suppression of flavivirus transmission from animal hosts to mosquitoes with a mosquito-delivered vaccine

Dan Wen,
Limin S. Ding,
Yanan Zhang,
Xiaoye Li,
Xing Zhang,
Fei Yuan,
Tongbiao Zhao,
Aihua Zheng

Affiliations

Dan Wen: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences
Limin S. Ding: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences
Yanan Zhang: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences
Xiaoye Li: College of life sciences, Henan Normal University
Xing Zhang: College of life sciences, University of Chinese Academy of Sciences
Fei Yuan: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences
Tongbiao Zhao: State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Institute for Stem Cell and Regeneration, Chinese Academy of Sciences
Aihua Zheng: State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-35407-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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Based on previous research that the Chaoyang virus is an insect-specific flavivirus, only able to replicate in insects and insect cells, authors present this proof-of-concept mosquito-delivered vaccine; they construct a Zika virus focused candidate that can be delivered by mosquito bite, and assess the immune response and protection in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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