Nature Communications (Mar 2020)
Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
- Debia Wakhloo,
- Franziska Scharkowski,
- Yasmina Curto,
- Umer Javed Butt,
- Vikas Bansal,
- Agnes A. Steixner-Kumar,
- Liane Wüstefeld,
- Ashish Rajput,
- Sahab Arinrad,
- Matthias R. Zillmann,
- Anna Seelbach,
- Imam Hassouna,
- Katharina Schneider,
- Abdul Qadir Ibrahim,
- Hauke B. Werner,
- Henrik Martens,
- Kamilla Miskowiak,
- Sonja M. Wojcik,
- Stefan Bonn,
- Juan Nacher,
- Klaus-Armin Nave,
- Hannelore Ehrenreich
Affiliations
- Debia Wakhloo
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Franziska Scharkowski
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Yasmina Curto
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Umer Javed Butt
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Vikas Bansal
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Agnes A. Steixner-Kumar
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Liane Wüstefeld
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Ashish Rajput
- Institute of Medical Systems Biology, Center for Molecular Neurobiology, University Clinic Hamburg-Eppendorf
- Sahab Arinrad
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Matthias R. Zillmann
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Anna Seelbach
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Imam Hassouna
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Katharina Schneider
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- Abdul Qadir Ibrahim
- Institute of Medical Systems Biology, Center for Molecular Neurobiology, University Clinic Hamburg-Eppendorf
- Hauke B. Werner
- Department of Neurogenetics, Max Planck Institute of Experimental Medicine
- Henrik Martens
- Synaptic Systems GmbH
- Kamilla Miskowiak
- Copenhagen Affective Disorder Research Centre, Psychiatric Centre Copenhagen, Copenhagen University Hospital, Rigshospitalet
- Sonja M. Wojcik
- Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine
- Stefan Bonn
- Institute of Medical Systems Biology, Center for Molecular Neurobiology, University Clinic Hamburg-Eppendorf
- Juan Nacher
- Neurobiology Unit, Program in Neurosciences and Interdisciplinary Research Structure for Biotechnology and Biomedicine (BIOTECMED), Universitat de València
- Klaus-Armin Nave
- Department of Neurogenetics, Max Planck Institute of Experimental Medicine
- Hannelore Ehrenreich
- Clinical Neuroscience, Max Planck Institute of Experimental Medicine
- DOI
- https://doi.org/10.1038/s41467-020-15041-1
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
EPO treatment improves cognition, but underlying mechanisms were unknown. Here the authors describe a regulatory loop in which brain networks challenged by cognitive tasks drift into functional hypoxia that drives—via neuronal EPO synthesis—neurodifferentiation and dendritic spine formation.
