Macrophage-Derived MMP-9 and MMP-2 are Closely Related to the Rupture of the Fibrous Capsule of Hepatocellular Carcinoma Leading to Tumor Invasion

Quanwei Cui; Xuben Wang; Yongwei Zhang; Yiqing Shen; Yeben Qian

doi:10.1186/s12575-023-00196-0

Biological Procedures Online (Mar 2023)

Macrophage-Derived MMP-9 and MMP-2 are Closely Related to the Rupture of the Fibrous Capsule of Hepatocellular Carcinoma Leading to Tumor Invasion

Quanwei Cui,
Xuben Wang,
Yongwei Zhang,
Yiqing Shen,
Yeben Qian

Affiliations

Quanwei Cui: Department of General Surgery, The First Affiliated Hospital of Anhui Medical University
Xuben Wang: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Yongwei Zhang: Department of General Surgery, Anqing First People’s Hospital Affiliated to Anhui Medical University
Yiqing Shen: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Yeben Qian: Department of General Surgery, The First Affiliated Hospital of Anhui Medical University

DOI: https://doi.org/10.1186/s12575-023-00196-0
Journal volume & issue: Vol. 25, no. 1
pp. 1 – 13

Abstract

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Highlights • HCC capsule broken leading to tumor invasion • Macrophage-derived MMP-9/MMP-2 were closely related to the rupture of the FC of HCC • MMP-9/MMP-2 was able to discriminate effectively between ruptured FC and intact FC Graphical Abstract

Published in Biological Procedures Online

ISSN: 1480-9222 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://biologicalproceduresonline.biomedcentral.com/

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Abstract

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