Diagnostics (Nov 2023)

Update on the Pathology of Pediatric Liver Tumors: A Pictorial Review

  • Priyanka Bhagat,
  • Mukul Vij,
  • Lexmi Priya Raju,
  • Gowripriya Gowrishankar,
  • Jagadeesh Menon,
  • Naresh Shanmugam,
  • Ilankumaran Kaliamoorthy,
  • Ashwin Rammohan,
  • Mohamed Rela

DOI
https://doi.org/10.3390/diagnostics13233524
Journal volume & issue
Vol. 13, no. 23
p. 3524

Abstract

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Liver tumors in children are uncommon and show remarkable morphologic heterogeneity. Pediatric tumors may arise from either the epithelial or mesenchymal component of the liver and rarely may also show both lines of differentiation. Both benign and malignant liver tumors have been reported in children. The most common pediatric liver tumors by age are benign hepatic infantile hemangiomas in neonates and infants, malignant hepatoblastoma in infants and toddlers, and malignant hepatocellular carcinoma in teenagers. Here, we provide an up-to-date review of pediatric liver tumors. We discuss the clinical presentation, imaging findings, pathology, and relevant molecular features that can help in the correct identification of these tumors, which is important in managing these children.

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