Nature Communications (Jan 2020)
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
- Susan A. Kennedy,
- Mohamed-Ali Jarboui,
- Sriganesh Srihari,
- Cinzia Raso,
- Kenneth Bryan,
- Layal Dernayka,
- Theodosia Charitou,
- Manuel Bernal-Llinares,
- Carlos Herrera-Montavez,
- Aleksandar Krstic,
- David Matallanas,
- Max Kotlyar,
- Igor Jurisica,
- Jasna Curak,
- Victoria Wong,
- Igor Stagljar,
- Thierry LeBihan,
- Lisa Imrie,
- Priyanka Pillai,
- Miriam A. Lynn,
- Erik Fasterius,
- Cristina Al-Khalili Szigyarto,
- James Breen,
- Christina Kiel,
- Luis Serrano,
- Nora Rauch,
- Oleksii Rukhlenko,
- Boris N. Kholodenko,
- Luis F. Iglesias-Martinez,
- Colm J. Ryan,
- Ruth Pilkington,
- Patrizia Cammareri,
- Owen Sansom,
- Steven Shave,
- Manfred Auer,
- Nicola Horn,
- Franziska Klose,
- Marius Ueffing,
- Karsten Boldt,
- David J. Lynn,
- Walter Kolch
Affiliations
- Susan A. Kennedy
- Systems Biology Ireland, University College Dublin
- Mohamed-Ali Jarboui
- Institute for Ophthalmic Research, University of Tübingen
- Sriganesh Srihari
- EMBL Australia Group, South Australian Health and Medical Research Institute
- Cinzia Raso
- Systems Biology Ireland, University College Dublin
- Kenneth Bryan
- EMBL Australia Group, South Australian Health and Medical Research Institute
- Layal Dernayka
- Institute for Ophthalmic Research, University of Tübingen
- Theodosia Charitou
- Systems Biology Ireland, University College Dublin
- Manuel Bernal-Llinares
- EMBL Australia Group, South Australian Health and Medical Research Institute
- Carlos Herrera-Montavez
- Systems Biology Ireland, University College Dublin
- Aleksandar Krstic
- Systems Biology Ireland, University College Dublin
- David Matallanas
- Systems Biology Ireland, University College Dublin
- Max Kotlyar
- Krembil Research Institute, University Health Network
- Igor Jurisica
- Krembil Research Institute, University Health Network
- Jasna Curak
- Donnelly Centre, University of Toronto
- Victoria Wong
- Donnelly Centre, University of Toronto
- Igor Stagljar
- Donnelly Centre, University of Toronto
- Thierry LeBihan
- Synthetic and Systems Biology, University of Edinburgh
- Lisa Imrie
- Synthetic and Systems Biology, University of Edinburgh
- Priyanka Pillai
- EMBL Australia Group, South Australian Health and Medical Research Institute
- Miriam A. Lynn
- EMBL Australia Group, South Australian Health and Medical Research Institute
- Erik Fasterius
- School of Biotechnology, KTH Royal Institute of Technology
- Cristina Al-Khalili Szigyarto
- School of Biotechnology, KTH Royal Institute of Technology
- James Breen
- School of Biological Sciences, University of Adelaide Bioinformatics Hub
- Christina Kiel
- Systems Biology Ireland, University College Dublin
- Luis Serrano
- Centre for Genomic Regulation, Barcelona Institute of Science and Technology
- Nora Rauch
- Systems Biology Ireland, University College Dublin
- Oleksii Rukhlenko
- Systems Biology Ireland, University College Dublin
- Boris N. Kholodenko
- Systems Biology Ireland, University College Dublin
- Luis F. Iglesias-Martinez
- Systems Biology Ireland, University College Dublin
- Colm J. Ryan
- Systems Biology Ireland, University College Dublin
- Ruth Pilkington
- Systems Biology Ireland, University College Dublin
- Patrizia Cammareri
- Cancer Research UK Beatson Institute
- Owen Sansom
- Cancer Research UK Beatson Institute
- Steven Shave
- School of Biological Sciences and School of Biomedical Sciences, University of Edinburgh
- Manfred Auer
- School of Biological Sciences and School of Biomedical Sciences, University of Edinburgh
- Nicola Horn
- Institute for Ophthalmic Research, University of Tübingen
- Franziska Klose
- Institute for Ophthalmic Research, University of Tübingen
- Marius Ueffing
- Institute for Ophthalmic Research, University of Tübingen
- Karsten Boldt
- Institute for Ophthalmic Research, University of Tübingen
- David J. Lynn
- EMBL Australia Group, South Australian Health and Medical Research Institute
- Walter Kolch
- Systems Biology Ireland, University College Dublin
- DOI
- https://doi.org/10.1038/s41467-019-14224-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Kras is often mutated in colorectal cancer but how this oncogenic mutation alters signalling pathways globally is undetermined. Here, the authors analyse how this mutation affects protein interaction networks and signal flow showing an extensive re‐wiring of signalling in response to KRas mutation
