A case of pleural mesothelioma with immunohistochemical staining positive for Krebs von den Lungen-6

Yugo Matsumura; Seidai Sato; Keiko Haji; Takeshi Masuda; Hiroto Yoneda; Hirokazu Ogino; Hirohisa Ogawa; Masaki Hanibuchi; Noboru Hattori; Yasuhiko Nishioka

Respiratory Medicine Case Reports (Jan 2024)

A case of pleural mesothelioma with immunohistochemical staining positive for Krebs von den Lungen-6

Yugo Matsumura,
Seidai Sato,
Keiko Haji,
Takeshi Masuda,
Hiroto Yoneda,
Hirokazu Ogino,
Hirohisa Ogawa,
Masaki Hanibuchi,
Noboru Hattori,
Yasuhiko Nishioka

Affiliations

Yugo Matsumura: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan
Seidai Sato: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan
Keiko Haji: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan
Takeshi Masuda: Department of Respiratory Medicine, Hiroshima University Hospital, Hiroshima, Japan
Hiroto Yoneda: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan
Hirokazu Ogino: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan
Hirohisa Ogawa: Department of Pathology and Laboratory Medicine, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan
Masaki Hanibuchi: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan; Department of Community Medicine for Respirology, Hematology and Metabolism, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan
Noboru Hattori: Department of Respiratory Medicine, Hiroshima University Hospital, Hiroshima, Japan
Yasuhiko Nishioka: Department of Respiratory Medicine and Rheumatology, Graduate School of Biomedical Sciences, Tokushima University, Tokushima, Japan; Corresponding author. Department of Respiratory Medicine and Rheumatology Graduate School of Biomedical Sciences, Tokushima University, 3Kuramoto-cho, Tokushima, 770-8503, Japan.

Journal volume & issue: Vol. 50
p. 102040

Abstract

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A 71-year-old male visited a hospital with a chief complaint of exertional dyspnea. A chest CT revealed multiple nodular lesions on the parietal pleura. Thoracoscopic pleural biopsy was performed resulting in a diagnosis of pleural mesothelioma with epithelioid type. When chemotherapy was initially initiated, his serum level of Krebs von den Lungen-6 (KL-6) was high. However, once chemotherapy was started, the serum KL-6 level gradually decreased with tumor shrinkage. Immunohistochemical staining revealed the expression of KL-6 from the tumor cells. This is the first report of KL-6 production directly from tumor cells in epithelial-type pleural mesothelioma.

Published in Respiratory Medicine Case Reports

ISSN: 2213-0071 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the respiratory system
Website: http://www.journals.elsevier.com/respiratory-medicine-case-reports/

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