Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis

Rebecca Boiarsky; Nicholas J. Haradhvala; Jean-Baptiste Alberge; Romanos Sklavenitis-Pistofidis; Tarek H. Mouhieddine; Oksana Zavidij; Ming-Chieh Shih; Danielle Firer; Mendy Miller; Habib El-Khoury; Shankara K. Anand; François Aguet; David Sontag; Irene M. Ghobrial; Gad Getz

doi:10.1038/s41467-022-33944-z

Nature Communications (Nov 2022)

Single cell characterization of myeloma and its precursor conditions reveals transcriptional signatures of early tumorigenesis

Rebecca Boiarsky,
Nicholas J. Haradhvala,
Jean-Baptiste Alberge,
Romanos Sklavenitis-Pistofidis,
Tarek H. Mouhieddine,
Oksana Zavidij,
Ming-Chieh Shih,
Danielle Firer,
Mendy Miller,
Habib El-Khoury,
Shankara K. Anand,
François Aguet,
David Sontag,
Irene M. Ghobrial,
Gad Getz

Affiliations

Rebecca Boiarsky: Broad Institute of MIT and Harvard
Nicholas J. Haradhvala: Broad Institute of MIT and Harvard
Jean-Baptiste Alberge: Broad Institute of MIT and Harvard
Romanos Sklavenitis-Pistofidis: Broad Institute of MIT and Harvard
Tarek H. Mouhieddine: Division of Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
Oksana Zavidij: Constellation Pharmaceuticals a MorphoSys Company
Ming-Chieh Shih: CSAIL and IMES, Massachusetts Institute of Technology
Danielle Firer: Broad Institute of MIT and Harvard
Mendy Miller: Broad Institute of MIT and Harvard
Habib El-Khoury: Department of Medical Oncology, Dana-Farber Cancer Institute
Shankara K. Anand: Broad Institute of MIT and Harvard
François Aguet: Broad Institute of MIT and Harvard
David Sontag: Broad Institute of MIT and Harvard
Irene M. Ghobrial: Broad Institute of MIT and Harvard
Gad Getz: Broad Institute of MIT and Harvard

DOI: https://doi.org/10.1038/s41467-022-33944-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Development of multiple myeloma is preceded by precursor conditions. Here, the authors use single cell RNA-sequencing of plasma cells from patients across disease stages to identify genomic signatures present even at the earliest stages of disease.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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