Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription

Nian Liu; Jiacheng He; Dongdong Fan; Yang Gu; Jianyi Wang; Huimu Li; Xiaoxiao Zhu; Ying Du; Yong Tian; Benyu Liu; Zusen Fan

doi:10.1038/s41467-022-32322-z

Nature Communications (Aug 2022)

Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription

Nian Liu,
Jiacheng He,
Dongdong Fan,
Yang Gu,
Jianyi Wang,
Huimu Li,
Xiaoxiao Zhu,
Ying Du,
Yong Tian,
Benyu Liu,
Zusen Fan

Affiliations

Nian Liu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jiacheng He: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Dongdong Fan: Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
Yang Gu: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Jianyi Wang: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Huimu Li: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Xiaoxiao Zhu: Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
Ying Du: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
Yong Tian: University of Chinese Academy of Sciences
Benyu Liu: Research Center of Basic Medicine, Academy of Medical Sciences, Zhengzhou University
Zusen Fan: Key Laboratory of Infection and Immunity of CAS, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-022-32322-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Innate lymphoid cells (ILC) have been shown to be involved in a range of inflammatory contexts but how their cellular lineage is regulated is not fully established. Here the authors show a role for circular RNA circTmem241 in the differentiation of ILC3 via initiation of Elk3 transcription.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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