Virulence (Dec 2023)
Evaluation of the safety, immunogenicity and efficacy of a new live-attenuated lumpy skin disease vaccine in India
- Naveen Kumar,
- Sanjay Barua,
- Ram Kumar,
- Nitin Khandelwal,
- Amit Kumar,
- Assim Verma,
- Lokender Singh,
- Bhagraj Godara,
- Yogesh Chander,
- Garvit Kumar,
- Thachamvally Riyesh,
- Deepak Kumar Sharma,
- Anubha Pathak,
- Sanjay Kumar,
- Ramesh Kumar Dedar,
- Vishal Mehta,
- Mitesh Gaur,
- Bhupendra Bhardwaj,
- Vithilesh Vyas,
- Sarjeet Chaudhary,
- Vijaypal Yadav,
- Adrish Bhati,
- Rakesh Kaul,
- Arif Bashir,
- Anjum Andrabi,
- Raja Wasim Yousuf,
- Abhimanyu Koul,
- Subhash Kachhawaha,
- Amol Gurav,
- Siddharth Gautam,
- Hari Audh Tiwari,
- Vijay Kumar Munjal,
- Madhurendu K. Gupta,
- Rajender Kumar,
- Baldev R. Gulati,
- Jyoti Misri,
- Ashok Kumar,
- Ashok Kumar Mohanty,
- Sukdeb Nandi,
- Karam Pal Singh,
- Yash Pal,
- Triveni Dutt,
- Bhupendra N. Tripathi
Affiliations
- Naveen Kumar
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Sanjay Barua
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Ram Kumar
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Nitin Khandelwal
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Amit Kumar
- Indian Veterinary Research Institute, Mukteswar, India
- Assim Verma
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Lokender Singh
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Bhagraj Godara
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Yogesh Chander
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Garvit Kumar
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Thachamvally Riyesh
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Deepak Kumar Sharma
- Department of Veterinary Microbiology, College of Veterinary and Animal Science, Udaipur, India
- Anubha Pathak
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Sanjay Kumar
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Ramesh Kumar Dedar
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Vishal Mehta
- Department of Animal Husbandry, Banswara, Rajasthan, India
- Mitesh Gaur
- Department of Veterinary Gynaecology and Obstetrics, College of Veterinary and Animal Science, Udaipur, India
- Bhupendra Bhardwaj
- Department of Animal Husbandry, Udaipur, Rajasthan, India
- Vithilesh Vyas
- Department of Animal Husbandry, Jodhpur, Rajasthan, India
- Sarjeet Chaudhary
- Department of Animal Husbandry, Alwar, Rajasthan, India
- Vijaypal Yadav
- Department of Animal Husbandry, Alwar, Rajasthan, India
- Adrish Bhati
- Livestock Research station, Nohar, Rajasthan, India
- Rakesh Kaul
- Animal Husbandry Department, Jammu and Kashmir, India
- Arif Bashir
- Animal Husbandry Department, Jammu and Kashmir, India
- Anjum Andrabi
- Animal Husbandry Department, Jammu and Kashmir, India
- Raja Wasim Yousuf
- Animal Husbandry Department, Jammu and Kashmir, India
- Abhimanyu Koul
- Animal Husbandry Department, Jammu and Kashmir, India
- Subhash Kachhawaha
- Krishi Vigyan Kendra, ICAR-Central Arid Zone Research Institute, Jodhpur, India
- Amol Gurav
- Indian Veterinary Research Institute, Mukteswar, India
- Siddharth Gautam
- Indian Veterinary Research Institute, Mukteswar, India
- Hari Audh Tiwari
- Hasanand Gaushala, Vrindavan, Mathura, India
- Vijay Kumar Munjal
- Bovine Sperm Station and Research Centre, Hisar, India
- Madhurendu K. Gupta
- Department of Veterinary Pathology, Birsa Agricultural University, Ranchi, India
- Rajender Kumar
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Baldev R. Gulati
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Jyoti Misri
- Animal Science Division, Indian Council of Agricultural Research, India
- Ashok Kumar
- Animal Science Division, Indian Council of Agricultural Research, India
- Ashok Kumar Mohanty
- Indian Veterinary Research Institute, Mukteswar, India
- Sukdeb Nandi
- Centre for Animal Disease Research and Diagnosis, Indian Veterinary Research Institute, Izatnagar, India
- Karam Pal Singh
- Centre for Animal Disease Research and Diagnosis, Indian Veterinary Research Institute, Izatnagar, India
- Yash Pal
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- Triveni Dutt
- Centre for Animal Disease Research and Diagnosis, Indian Veterinary Research Institute, Izatnagar, India
- Bhupendra N. Tripathi
- National Centre for Veterinary Type Cultures, ICAR-National Research Centre on Equines, Hisar, India
- DOI
- https://doi.org/10.1080/21505594.2023.2190647
- Journal volume & issue
-
Vol. 14,
no. 1
Abstract
ABSTRACTLumpy skin disease (LSD) was reported for the first time in India in 2019 and since then, it has become endemic. Since a homologous (LSD-virus based) vaccine was not available in the country, goatpox virus (GPV)-based heterologous vaccine was authorized for mass immunization to induce protection against LSD in cattle. This study describes the evaluation of safety, immunogenicity and efficacy of a new live-attenuated LSD vaccine developed by using an Indian field strain, isolated in 2019 from cattle. The virus was attenuated by continuous passage (P = 50) in Vero cells. The vaccine (50th LSDV passage in Vero cells, named as Lumpi-ProVacInd) did not induce any local or systemic reaction upon its experimental inoculation in calves (n = 10). At day 30 post-vaccination (pv), the vaccinated animals were shown to develop antibody- and cell-mediated immune responses and exhibited complete protection upon virulent LSDV challenge. A minimum Neethling response (0.018% animals; 5 out of 26,940 animals) of the vaccine was observed in the field trials conducted in 26,940 animals. There was no significant reduction in the milk yield in lactating animals (n = 10108), besides there was no abortion or any other reproductive disorder in the pregnant animals (n = 2889). Sero-conversion was observed in 85.18% animals in the field by day 30 pv.
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