6-Acetonylisoxanthopterin: A Potent Inhibitor of Sepiapterin Reductase

Nakanishi A.; Goto M.; Katoh S.; Sueoka T.

doi:10.1515/pteridines.1991.3.3.165

Pteridines (Sep 1991)

6-Acetonylisoxanthopterin: A Potent Inhibitor of Sepiapterin Reductase

Nakanishi A.,
Goto M.,
Katoh S.,
Sueoka T.

Affiliations

Nakanishi A.: Department of Chemistry, Gakushuin University, Toshima-ku, Tokyo, 171, Japan
Goto M.: Department of Chemistry, Gakushuin University, Toshima-ku, Tokyo, 171, Japan
Katoh S.: Department of Biochemistry, Meikai University School of Dentistry, Sakado, Saitama, 350-02. Japan
Sueoka T.: Department of Biochemistry, Meikai University School of Dentistry, Sakado, Saitama, 350-02. Japan

DOI: https://doi.org/10.1515/pteridines.1991.3.3.165
Journal volume & issue: Vol. 3, no. 3
pp. 165 – 166

Abstract

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The inhibitory effect of 6-/7-substituted (2'-oxo) pteridines and ichthyopterin was examined for sepiapterin reductase. 6-Acetonylisoxanthopterin and 6-acetonyl-2,4-diamino-7-hydroxypteridine showed pronounced competitive inhibitory effects to sepiapterin reductase and Ki values were 0.38 μM and 90 μM, respectively. Ichthyopterin and 6-acetonyl-7-hydroxylumazine showed weak noncompetitive inhibitory effects and Ki values were 2.4 mM and 1.1 mM, respectively. 7-Acetonylxanthopterin exhibited no inhibition to sepiapterin reductase.

Published in Pteridines

ISSN: 0933-4807 (Print); 2195-4720 (Online)
Publisher: De Gruyter
Country of publisher: Poland
LCC subjects: Science: Chemistry: Crystallography
Website: https://www.degruyter.com/view/j/pteridines

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