Haematologica (Apr 2012)

MicroRNA profiling of follicular lymphoma identifies microRNAs related to cell proliferation and tumor response

  • Weixin Wang,
  • Meghan Corrigan-Cummins,
  • Justin Hudson,
  • Irina Maric,
  • Olga Simakova,
  • Sattva S. Neelapu,
  • Larry W. Kwak,
  • John E. Janik,
  • Barry Gause,
  • Elaine S. Jaffe,
  • Katherine R. Calvo

DOI
https://doi.org/10.3324/haematol.2011.048132
Journal volume & issue
Vol. 97, no. 4

Abstract

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Background MicroRNAs can play an important role in tumorigenesis through post-transcriptional regulation of gene expression, and are not well characterized in follicular lymphoma.Design and Methods MicroRNA profiles of enriched follicular lymphoma tumor cells from 16 patients were generated by assaying 851 human microRNAs. Tandem gene expression profiles were obtained for predicting microRNA targets.Results The expression of 133 microRNAs was significantly different (> 2-fold; P