Vascular endothelium activation mechanisms study іn patients with psoriasis and essential hypertension

Abstract

The aim. To study Vascular Endothelial Growth Factor-A expression in patients with both psoriasis and hypertension. Methods and results. 102 patients were included. Vascular Endothelial Growth Factor-A level was detected with indirect ELISA method. It was found that VEGF-A level was maximal in patients with psoriasis and hypertension stage II - 694.44 (567.36–829.87) pg/ml. That was statistically significantly higher (p<0,01) than in patients with psoriasis and more than 5 times (p<0,01) higher than VEGF-A levels patients with essential hypertension. At the same time, vascular endothelial growth factor level in patients with psoriasis without essential hypertension was higher in 3.5 times (p<0,01) when compared with group of patients with essential hypertension, which did not exceed 300 pg/ml. This indicates it is most active angiogenesis in patients with a combination of psoriasis and essential hypertension. Conclusion. The results indicated the direct relationship between the reliable indicators of VEGF-A expression and dermatosis clinical course severity in patients with both psoriasis and essential hypertension.

Keywords

• Vascular Endothelial Growth Factor-A
• Psoriasis
• Essential Hypertension