Synchronous BRCA2 positive ovarian carcinoma with ALK positive NSCLC: Double trouble

Abstract

Lung cancer being a molecularly distinct entity in the female population, multiple primary tumors including the genital and urinary tract malignancies with lung carcinoma is rare and constitutes a unique set of patient population. This case report serves to illustrate the rarity of multiple primary tumor involving ovarian carcinoma with ALK positive lung cancer. Additionally high throughput sequencing revealed a germline BRCA2 mutation causing alteration of splice site. This report highlights the occurrence of multiple primary tumors in this patient possibly due to BRCA2 predisposition.

Keywords

• NSCLC
• ALK
• BRCA2
• PARPi
• Metachronous and synchronous malignancy