KAJIAN MOLEKULER RESISTENSI Candida albicans TERHADAP ANTIFUNGI

Abstract

Abstract: Candida albicans is one of the species Candida which mostly cause infection in human. Antifungal agent azole, polyene, echinocandin, and flucytosine are commonly used for Candida albicans infection treatment. The increasing using antifungal agent will cause antifungal resistance. Most of this resistance happen through gene mutation. This mutation may influence efflux pumps, interaction of the drug and the target enzyme, the component of fungal structure biosynthesis, and conformation of compound in fungal cell. Keywords: Candida albicans, antifungal agent, resistance, gene mutation