Nature Communications (May 2021)
Population genomics provides insights into the evolution and adaptation to humans of the waterborne pathogen Mycobacterium kansasii
- Tao Luo,
- Peng Xu,
- Yangyi Zhang,
- Jessica L. Porter,
- Marwan Ghanem,
- Qingyun Liu,
- Yuan Jiang,
- Jing Li,
- Qing Miao,
- Bijie Hu,
- Benjamin P. Howden,
- Janet A. M. Fyfe,
- Maria Globan,
- Wencong He,
- Ping He,
- Yiting Wang,
- Houming Liu,
- Howard E. Takiff,
- Yanlin Zhao,
- Xinchun Chen,
- Qichao Pan,
- Marcel A. Behr,
- Timothy P. Stinear,
- Qian Gao
Affiliations
- Tao Luo
- Department of Pathogen Biology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University
- Peng Xu
- Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Medical College and School of Basic Medical Sciences, Shanghai Public Health Clinical Center, Fudan University
- Yangyi Zhang
- Department of Tuberculosis Control, Shanghai Municipal Centre for Disease Control and Prevention
- Jessica L. Porter
- Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne
- Marwan Ghanem
- Department of Microbiology and Immunology, McGill University and McGill International TB Centre
- Qingyun Liu
- Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Medical College and School of Basic Medical Sciences, Shanghai Public Health Clinical Center, Fudan University
- Yuan Jiang
- Department of Tuberculosis Control, Shanghai Municipal Centre for Disease Control and Prevention
- Jing Li
- Department of Tuberculosis Control, Shanghai Municipal Centre for Disease Control and Prevention
- Qing Miao
- Department of Infectious Diseases, Zhongshan Hospital, Fudan University
- Bijie Hu
- Department of Infectious Diseases, Zhongshan Hospital, Fudan University
- Benjamin P. Howden
- Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne
- Janet A. M. Fyfe
- Victorian Infectious Diseases Reference Laboratory, Doherty Institute for Infection and Immunity, Melbourne Health
- Maria Globan
- Victorian Infectious Diseases Reference Laboratory, Doherty Institute for Infection and Immunity, Melbourne Health
- Wencong He
- Chinese Center for Disease Control and Prevention and Beijing Tuberculosis and Thoracic Tumor Research Institute
- Ping He
- Chinese Center for Disease Control and Prevention and Beijing Tuberculosis and Thoracic Tumor Research Institute
- Yiting Wang
- Chinese Center for Disease Control and Prevention and Beijing Tuberculosis and Thoracic Tumor Research Institute
- Houming Liu
- Department of Clinical Laboratory, The Third People’s Hospital of Shenzhen, Southern University of Science and Technology
- Howard E. Takiff
- Unité de Pathogenetique Integrée Mycobacterienne, Institut Pasteur
- Yanlin Zhao
- Chinese Center for Disease Control and Prevention and Beijing Tuberculosis and Thoracic Tumor Research Institute
- Xinchun Chen
- Guangdong Provincial Key Laboratory of Regional Immunity and Diseases, Department of Pathogen Biology, Shenzhen University School of Medicine
- Qichao Pan
- Department of Tuberculosis Control, Shanghai Municipal Centre for Disease Control and Prevention
- Marcel A. Behr
- Department of Microbiology and Immunology, McGill University and McGill International TB Centre
- Timothy P. Stinear
- Department of Microbiology and Immunology, Doherty Institute for Infection and Immunity, University of Melbourne
- Qian Gao
- Shanghai Institute of Infectious Disease and Biosecurity, Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Medical College and School of Basic Medical Sciences, Shanghai Public Health Clinical Center, Fudan University
- DOI
- https://doi.org/10.1038/s41467-021-22760-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
Mycobacterium kansasii can cause serious pulmonary disease. Here, the authors present a population genomics analysis of 358 environmental and clinical isolates from around the world, supporting the idea that municipal water is a main source of infection, and shedding light into the pathogen’s diversity and adaptation to the human host.
