Revista Científica Estudiantil 2 de Diciembre (Mar 2023)
Pathophysiological mechanisms involved in haemostatic and thromboinflammatory alterations developed by SARS-CoV-2 virus
Abstract
Introduction: the current COVID-2019 pandemic is the third man-made epidemic from coronavirus. The disease is diverse so there are elements not yet understood in infection, inflammation and hematological pathology. Objective: to describe the pathophysiological aspects involved in hemostatic and thromboinflammatory alterations in the face of infection by the SARS-CoV-2 virus. Method: a bibliographic review was carried out in the databases PubMed, SciElo, Medline, Science Direct, Medigraphic and Scopus, between July and August 2021. A total of 45 investigations were consulted between original articles, review articles and case presentations in Spanish and English languages. The articles with the greatest scientific impact that were related to the topic addressed and the most up-to-date were selected, out of a total of 30 bibliographic sources. Development: the immune system of the infected organism as part of its own response triggers a series of thrombotic events. These alterations are observed in almost all vascular beds. The SARS-Cov-2 virus binds to Angiotensin Converting Enzyme 2 and causes cell damage. Platelets have been shown to have changes in gene expression and their function in COVID-19. Conclusions: The pathophysiological mechanisms produced by SARS-CoV-2 are based on the increase in prothrombotic factors and the cytokine storm. The latter is produced by the body and generates a series of events translated into coagulopathy and thrombosis. Thromboinflammatory changes are more common and cause damage to various organs with fatal outcomes.
