Cell Reports Medicine (Apr 2021)
Hypoxia-inducible CAR expression: An answer to the on-target/off-tumor dilemma?
Abstract
On-target/off-tumor toxicity is one of the major concerns regarding CAR T-cell therapy. Kosti et al.1 demonstrate that this form of toxicity can be prevented by designing a CAR whose expression is controlled by oxygen levels in the tumor environment.
