Diagnostics (Mar 2024)

Long COVID: Long-Term Impact of SARS-CoV2

  • Huda Makhluf,
  • Henry Madany,
  • Kenneth Kim

DOI
https://doi.org/10.3390/diagnostics14070711
Journal volume & issue
Vol. 14, no. 7
p. 711

Abstract

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Four years post-pandemic, SARS-CoV-2 continues to affect many lives across the globe. An estimated 65 million people suffer from long COVID, a term used to encapsulate the post-acute sequelae of SARS-CoV-2 infections that affect multiple organ systems. Known symptoms include chronic fatigue syndrome, brain fog, cardiovascular issues, autoimmunity, dysautonomia, and clotting due to inflammation. Herein, we review long COVID symptoms, the proposed theories behind the pathology, diagnostics, treatments, and the clinical trials underway to explore treatments for viral persistence, autonomic and cognitive dysfunctions, sleep disturbances, fatigue, and exercise intolerance.

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