Scientific Reports (Oct 2024)
Rapid Campimetry in glaucoma – correspondence with standard perimetry and OCT
Abstract
Abstract The Rapid Campimetry (RC), a kinetic visual field test proved to reliably detect visual field defects within the central 10° degrees, the most crucial part for visual acuity and quality of life, affected even at very early stages of glaucoma, within a short measurement epoch, ~ 1 min. This study aims to further investigate RC correspondence with standard tests in glaucoma, namely standard automated perimetry (SAP) and optical coherence tomography (OCT) within 10° of visual field (VF). For this purpose, we included 41 participants, [21 glaucoma (GLA, mean age: 65.9 ± 12.4; 12 preperimetric eyes and 11 with VF defects) and 20 healthy controls (HC; mean age: 65.0 ± 10.3); 20 eyes]. At first, we compared the rate of detection/exclusion of VF defects in RC vs. SAP. Then, for those with VF defects (11 eyes), we investigated the 68-pointwise correspondence of 10 − 2 layout of RC and SAP. For functional and structural (SF) correspondence, pointwise correspondence of RC, SAP vs. OCTmacula [ macular ganglion cell thickness (GCL)] was also performed. Further, we compared sector-based correspondence of RC, SAP vs. OCTmacula accounting for GCL displacement at the fovea as well as sector-based correspondence with OCTdisc [peripapillary retinal nerve fiber layer thickness (pRNFL)]. Agreement estimates were reported along with Cohen Kappa ( $$\:\kappa\:$$ ) statistic. For overall performance, RC and SAP showed 100% agreement ( $$\:\kappa\:=1$$ ) for the exclusion of VF defects (HC and preperimetric GLA) and for detection of VF defects [11 eyes of 9 GLA, ( $$\:\kappa\:=1)$$ ]. Further, RC outperformed SAP in detection of arcuate scotomas, 7 vs. 5, respectively. Pointwise correspondence of VF defects (11 eyes), RC-SAP agreement reached 90% accuracy ( $$\:\kappa\:=0.77,\:substantial\:agreement$$ ). For SF correspondence, RC [SAP] showed 62% [69%] pointwise agreement with OCTmacula, ( $$\:\kappa\:=0.10\:\left[0.33\right]$$ ). For macular sector-based correspondence, SF correspondence improved and reached 83% [83%] agreement, ( $$\:\kappa\:=0.57\:\left[0.57\right]$$ ). For OCTdisc sector-based analysis, SF correspondence was highest, 100% [100%] agreement, ( $$\:\kappa\:=1\:\left[1\right]$$ ). Rapid Campimetry gave reproducible results in comparison to SAP and OCT with high potential as a screening VF method given its short testing duration, ~ 1 min in screening mode, and compatibility with telemedicine technologies upon future optimization and automation.
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