Factors influencing scar formation following Bacille Calmette-Guérin (BCG) vaccination
Paola Villanueva,
Nigel W. Crawford,
Mariana Garcia Croda,
Simone Collopy,
Bruno Araújo Jardim,
Tyane de Almeida Pinto Jardim,
Laurens Manning,
Michaela Lucas,
Helen Marshall,
Cristina Prat-Aymerich,
Alice Sawka,
Ketaki Sharma,
Darren Troeman,
Ushma Wadia,
Adilia Warris,
Nicholas Wood,
Nicole L. Messina,
Nigel Curtis,
Laure F. Pittet
Affiliations
Paola Villanueva
Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Infection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia; Infectious Diseases, Royal Children's Hospital Melbourne, Parkville, VIC, Australia; Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, VIC, Australia; Corresponding author.
Nigel W. Crawford
Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Infection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia; Department of General Medicine, Royal Children's Hospital Melbourne, Parkville, VIC, Australia; Immunisation Service, Royal Children's Hospital Melbourne, Parkville, VIC, Australia
Mariana Garcia Croda
School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, MS, Brazil
Simone Collopy
Department of Pediatrics, Universidade Estadual do Rio de Janeiro, Rio de Janeiro, Brazil
Bruno Araújo Jardim
Carlos Borborema Clinical Research Institute, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil
Tyane de Almeida Pinto Jardim
Carlos Borborema Clinical Research Institute, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil
Laurens Manning
Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia; School of Medicine, University of Western Australia, Perth, WA, Australia; Department of Infectious Diseases, Fiona Stanley Hospital, Perth, WA, Australia
Michaela Lucas
School of Medicine, University of Western Australia, Perth, WA, Australia; Department of Immunology, Sir Charles Gairdner Hospital, Perth, WA, Australia; Departments of Immunology, Perth Children's Hospital, Perth, WA, Australia; Department of Immunology, Pathwest, QE2 Medical Centre, Perth, WA, Australia
Helen Marshall
Robinson Research Institute and Adelaide Medical School, The University of Adelaide and Department of Paediatrics, The Women's and Children's Health Network, Australia
Cristina Prat-Aymerich
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands; Institut d'Investigació Germans Trias i Pujol, Departament de Genètica i Microbiologia, CIBER de enfermedades respiratorias (CIBERES), Instituto de Salud Carlos III, Universitat Autònoma de Barcelona, Catalunya, Badalona, Spain
Alice Sawka
Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, SA, Australia
Ketaki Sharma
National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia; The Children's Hospital at Westmead, Westmead, NSW, Australia
Darren Troeman
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands
Ushma Wadia
Wesfarmers Centre for Vaccines and Infectious Diseases, Telethon Kids Institute, Perth, WA, Australia
Adilia Warris
Medical Research Council Centre for Medical Mycology, University of Exeter, UK; Great Ormond Street Hospital, London, UK
Nicholas Wood
National Centre for Immunisation Research and Surveillance, Westmead, NSW, Australia; The Children's Hospital at Westmead, Westmead, NSW, Australia; The Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, University of Sydney, NSW, Australia
Nicole L. Messina
Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Infection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia
Nigel Curtis
Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Infection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia; Infectious Diseases, Royal Children's Hospital Melbourne, Parkville, VIC, Australia; Corresponding author. Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia.
Laure F. Pittet
Department of Paediatrics, The University of Melbourne, Parkville, VIC, Australia; Infection and Immunity, Murdoch Children's Research Institute, Parkville, VIC, Australia; Infectious Diseases, Royal Children's Hospital Melbourne, Parkville, VIC, Australia; Infectious Diseases Unit, Department of Paediatrics, Gynaecology and Obstetrics, Faculty of Medicine, University of Geneva and University Hospitals of Geneva, Geneva, Switzerland
The prevalence of scar formation following Bacille Calmette-Guérin (BCG) vaccination varies globally. The beneficial off-target effects of BCG are proposed to be stronger amongst children who develop a BCG scar. Within an international randomised trial (‘BCG vaccination to reduce the impact of coronavirus disease 2019 (COVID-19) in healthcare workers’; BRACE Trial), this nested prospective cohort study assessed the prevalence of and factors influencing scar formation, as well as participant perception of BCG scarring 12 months following vaccination . Amongst 3071 BCG-recipients, 2341 (76%) developed a BCG scar. Scar prevalence was lowest in Spain and highest in UK. Absence of post-injection wheal (OR 0.4, 95%CI 0.2–0.9), BCG revaccination (OR 1.7, 95%CI 1.3–2.0), female sex (OR 2.0, 95%CI 1.7–2.4), older age (OR 0.4, 95%CI 0.4–0.5) and study country (Brazil OR 1.6, 95%CI 1.3–2.0) influenced BCG scar prevalence. Of the 2341 participants with a BCG scar, 1806 (77%) did not mind having the scar. Participants more likely to not mind were those in Brazil, males and those with a prior BCG vaccination history. The majority (96%) did not regret having the vaccine.Both vaccination-related (amenable to optimisation) and individual-related factors affected BCG scar prevalence 12 months following BCG vaccination of adults, with implications for maximising the effectiveness of BCG vaccination.
