Volumetric evaluation of effects of platelet-rich fibrin and concentrated growth factor on early bone healing after endodontic microsurgery: a randomized controlled trial

Abstract

Abstract Background This randomized controlled clinical trial compared the effects of platelet-rich fibrin (PRF) and concentrated growth factor (CGF) on early bone healing after endodontic microsurgery. Methods Eighteen patients with an isolated periapical lesion 0.05). However, no significant difference was observed between the PRF and CGF groups. At the six-month follow-up, no significant differences were observed between the groups. Conclusions These results suggested that PRF and CGF promote early bone healing after endodontic microsurgery.

Keywords

• Endodontic microsurgery
• Bone defect
• Cone-beam computed tomography
• Platelet-rich fibrin
• Concentrated growth factor