Alʹmanah Kliničeskoj Mediciny (Feb 2016)

THE DEVELOPMENT OF DIAGNOSTICS AND ALIMENTARY PREVENTION SYSTEM OF NON-COMMUNICABLE DISEASES

  • A. V. Pogozheva,
  • E. Yu. Sorokina,
  • A. K. Baturin,
  • E. V. Peskova,
  • O. N. Makurina,
  • L. G. Levin,
  • T. V. Aristarkhova,
  • M. M. Korosteleva,
  • N. N. Denisova,
  • T. N. Solntseva,
  • L. V. Aleshina,
  • M. A. Toboleva

DOI
https://doi.org/10.18786/2072-0505-2015-1-67-74
Journal volume & issue
Vol. 1, no. 1
pp. 67 – 74

Abstract

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Background: Violation of dietary intake structure leads to changes in nutritional status. This contributes to the development of non-communicable diseases, which account for more than half of causes of death inRussia. Materials and methods: In a consultative and diagnostic center "Healthy Nutrition" of theInstituteofNutritionthe nutritional status of 3580 patients (mean age 48.4±0.3 years) has been examined, including genomic and post-translational analysis. 30.0% of patients were overweight and 34.1% were obese.Results: Analysis of actual dietary intake showed an increase in energy intake due to excess intake of total (44.2% energy) and saturated fat (13.6%). Serum biochemistry analyses revealed increased cholesterol levels in 68.7% of patients, increased low-density lipoprotein cholesterol in 63.9%, increased triglycerides in 22.5%, and increased blood glucose in 29.4%. The frequencies of risk alleles of genes associated with development of obesity and type 2 diabetes mellitus were as follows: 47.8% for the polymorphism rs9939609 (FTO gene), 8.3% for the polymorphism rs4994 (gene ADRB3), 60.2% for the polymorphism rs659366 (gene UCP2), 36.6% for the rs5219 polymorphism in the gene of ATPdependent potassium channel.Conclusion: These results can be used for development of a personalized diet based on assessment of a patient's nutritional status.

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