Semisynthesis of 6<i>β</i>-Acetoxyvouacapane Derivatives via the Ugi-Azide Multicomponent Reaction

Abstract

A semisynthesis of 6β-acetoxyvouacapane-1,5-disusbtituted tetrazoles derivatives from the leaves of Caesalpinia platyloba by using the Ugi-azide multicomponent reaction as a key step reaction is described. To our knowledge, this is the first report where a non-natural product such as 1,5-disusbtituted tetrazole has been linked to a natural product or derivate of a natural product, and beyond the biological relevance that the target molecules present, this work contributes to the area of natural products as well as multicomponent reactions.

Keywords

• 6<i>β</i>-acetoxyvouacapane
• 1,5-disusbtituted tetrazoles
• ugi-azide
• isocyanides
• semisynthesis